Predictive Value of Admission Blood Glucose Level in Acute Myocardial Infarction Clinical Trial
Official title:
Predictive ValueOf Admission Blood Glucose Level In Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Angioplasty
Coronary atherosclerosis is the leading cause of death worldwide. Diabetes mellitus is
associated with increased prevalence of coronary artery disease
Increased plasma glucose is a common feature in the acute phase of myocardial infarction,
even in patients without diabetes. Patients with stress hyperglycemia, but without previous
diagnosis of diabetes, were at increased risk of congestive heart failure, arrhythmia and
cardiogenic shock as well as increased both in-hospital and long-term mortality . Previous
studies have demonstrated larger infarct size and poorer prognosis inpatients with
hyperglycemia upon hospital admission compared with patients without hyperglycemia
It has been reported that stress hyperglycemia impairs microvascular circulation and may
lead to no-reflow phenomenon. No reflow phenomenon was significantly more frequent among
patients with hyperglycemia and increased progressively with increasing admission blood
glucose in patients with Acute Myocardial Infarction . Furthermore, patients with high
admission glucose are more likely to develop restenosis and require repeat revascularization
procedures compared with those with normal admission glucose and are also at increased risk
for repeated Myocardial Infarction, stent thrombosis and death.
| Status | Not yet recruiting |
| Enrollment | 100 |
| Est. completion date | June 1, 2019 |
| Est. primary completion date | December 1, 2018 |
| Accepts healthy volunteers | |
| Gender | All |
| Age group | N/A and older |
| Eligibility |
Inclusion Criteria: acute ST Segment Elevation Myocardial Infarction patients not known to have Diabetes Mellitus undergoing primary PCI. Exclusion Criteria: - patients known to have Diabetes mellitus (known diabetes mellitus on admission, which was treated with diet, oral glucose-lowering medication, and/or insulin). - Patients with prior Primary Percutaneous Intervention and/or Coronary Artery Bypass Graft (altering disease state). - Patients with severe liver or renal disease (altering disease state). - Patients with anemia, kidney disease or certain blood disorders (thalassemia). |
| Country | Name | City | State |
|---|---|---|---|
| n/a | |||
| Lead Sponsor | Collaborator |
|---|---|
| Assiut University |
Cura FA, L'Allier PL, Kapadia SR, Houghtaling PL, Dipaola LM, Ellis SG, Topol EJ, Brener SJ; GUSTO IIb and RAPPORT Investigators.. Predictors and prognosis of suboptimal coronary blood flow after primary coronary angioplasty in patients with acute myocard — View Citation
Gearhart MM, Parbhoo SK. Hyperglycemia in the critically ill patient. AACN Clin Issues. 2006 Jan-Mar;17(1):50-5. Review. — View Citation
Iwakura K, Ito H, Ikushima M, Kawano S, Okamura A, Asano K, Kuroda T, Tanaka K, Masuyama T, Hori M, Fujii K. Association between hyperglycemia and the no-reflow phenomenon in patients with acute myocardial infarction. J Am Coll Cardiol. 2003 Jan 1;41(1):1 — View Citation
Mehta RH, Harjai KJ, Cox D, Stone GW, Brodie B, Boura J, O'Neill W, Grines CL; Primary Angioplasty in Myocardial Infarction (PAMI) Investigators.. Clinical and angiographic correlates and outcomes of suboptimal coronary flow inpatients with acute myocardi — View Citation
Rasoul S, Ottervanger JP, Bilo HJ, Timmer JR, van 't Hof AW, Dambrink JH, Dikkeschei LD, Hoorntje JC, de Boer MJ, Zijlstra F. Glucose dysregulation in nondiabetic patients with ST-elevation myocardial infarction: acute and chronic glucose dysregulation in — View Citation
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Correlation of level of blood glucose on admission in patients with ST Segment Elevation Myocardial Infarction and Hospital Outcome | 1 month |