Diabetes Mellitus With Periodontal Disease Clinical Trial
Official title:
The Effect of Non‐Surgical Periodontal Therapy With Adjunctive Topical Doxycycline Gel on HbA1c in Patients With Type 2 Diabetes Mellitus (DM):A Randomized, Clinical Trial
Aim:
The purpose of this study is to investigate the effect of nonsurgical periodontal therapy
plus subgingivally doxycycline gel 3% on glycemic control in type 2 diabetes mellitus (type 2
DM) patients who have periodontitis.
Materials and methods:
A total of 24 type 2 DM patients with periodontitis will be selected for the study, and
randomly divided into two equal groups,who are at least 35 years of age and 16 teeth and type
II diabetes are (at least the last 3 months of diagnosis of diabetes and its FBS More than
110 have), and also with periodontal disease are chronic moderate (at least in three areas
Attachment level to a depth of 3-4 mm maxillary or mandibular been confirmed by clinical
examination and radiographic signs are being); Takes place. The initial HbA1c Patients should
be between 7-9 percent over the past three months has changed his medication also found the
necessary explanations on how to do that consent, Plaque index (PI) by Loe & Silness,
bleeding on probing (BOP) based on Carter and Barnes (if any bleeding number 1 and its
absence is 0), probing depth (PD) and clinical attachment levels (CAL) were recorded. "Group
1": (12 patients) was treated with oral hygiene instruction, scaling and root planing, and
doxycycline gel for 15 days; and "Group 2": (12 patients) has the same treatment but with
placebo gel, After 12 weeks their periodontal condition and Fasting blood sugar (FBS),
glycated hemoglobin (HbA1c) level, will be reevaluated.
Doxycycline downregulates the activity of matrix metalloproteinases (MMPs), key destructive enzymes in periodontal disease ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02845024 -
The Effect of Non-surgical Periodontal Therapy Plus Doxycycline on HbA1c in Patients With Type 2 Diabetes Mellitus
|
N/A | |
| Completed |
NCT04865809 -
Use of Ozonized Water With Toothpaste and Mousse in Non Surgical Periodontal Therapy for Patients With Diabetes Mellitus Type 1: a Randomized Clinical Trial.
|
N/A |