Pulmonary Disease, Chronic Obstructive Clinical Trial
Official title:
Evaluation of SERPINA1 Gene Polymorphisms in COPD as a Risk Factor for Periodontitis
Chronic obstructive pulmonary disease and periodontitis are chronic inflammatory diseases. The study aims to determine if the genetic polymorphism of SERPINA1 gene in patients with COPD serve as a risk factor for developing periodontitis.
periodontitis is a polymicrobial inflammatory disease caused by various modifiable and
non-modifiable risk factors. the non-modifiable risk factors include genetic polymorphisms
like the gene coding for alpha-1-antitrypsinase
COPD is a chronic inflammatory disease characterized by deterioration of lung function due
to loss of elasticity of the lungs.
SERPINA1 gene product has a protective role on the connective tissue components of both
lungs and gums.
Hence, this study tries to determine if the gene polymorphism in COPD serves as a risk
factor for developing periodontitis.
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Observational Model: Case Control, Time Perspective: Retrospective
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