E-nose Utility in the Diagnosis of Bacterial Infection in COPD

Pulmonary Disease, Chronic Obstructive (COPD) Clinical Trial

Official title: E-nose Utility in the Diagnosis of Bacterial Infection in Chronic Obstructive Pulmonary Disease (COPD)

Status Active, not recruiting

Clinical Trial Summary

Hypothesis: A commercial e-nose (Cyranose 320) is able to detect specific breathprints from patients with COPD and bacterial infection

Clinical Trial Description

Thirty to 50% of COPD patients have airway colonization with potentially pathogenic bacteria. This is associated with worse prognosis. Currently, diagnosis of bacterial colonization relies mainly upon quantitative sputum culture. However, this method lacks good sensitivity. The electronic nose is a novel device made up of nanosensors capable of detecting specific volatile organic compounds (VOCs). OBJECTIVES: Main 1) To assess the usefulness of the electronic nose in the diagnosis of bacterial colonization in COPD. Secondary 1) To define the VOCs pattern associated with bacterial colonization. 2) To study the pattern of pulmonary and systemic inflammation associated with bacterial colonization as well its relationship with the aforementioned VOCs patterns. ;

Study Design

Intervention Model: Single Group Assignment, Masking: Open Label

Related Conditions & MeSH terms

• Bacterial Infections
• Chronic Disease
• Lung Diseases
• Pulmonary Disease, Chronic Obstructive
• Pulmonary Disease, Chronic Obstructive (COPD)

• NCT number: NCT01976117
• Study type: Interventional
• Source: Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
• Status: Active, not recruiting
• Phase: N/A
• Start date: June 2012
• Completion date: December 2018