Non-ST Elevation Myocardial Infarction Clinical Trial
Official title:
Effect of the Interleukin-6 Receptor Antagonist Tocilizumab in Non-ST Elevation Myocardial Infarction - a Randomized, Double Blind, Placebo Controlled Study.
Acute coronary syndromes (ACS) are still associated with high morbidity and mortality,
despite several improvements in their management. This may indicate that important
pathogenic mechanisms contribute to both stable and unstable atherosclerotic disease
mechanisms.
Based upon previous research, the investigators believe that providing a block in the
damaging inflammatory loop though short term inhibition of Interleukin-6 receptor
signalling, could be an attractive therapeutic target in ACS; and of particular interest in
patients with non-ST elevation myocardial infarction (NSTEMI), a disease often characterized
by widespread coronary inflammation with multiple unstable plaques.
The investigators hypothesize that a single administration of the anti-Interleukin 6
receptor antagonist Tocilizumab, in patients with NSTEMI, may interrupt the
self-perpetuating inflammatory loops which could improve plaque stability, with potential
secondary beneficial effects on myocardial damage.
This will be investigated in a randomized, double blind, placebo-controlled study, including
a total of 120 patients.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Active, not recruiting |
NCT03278509 -
Evaluation of Decreased Usage of Betablockers After Myocardial Infarction in the SWEDEHEART Registry (REDUCE-SWEDEHEART)
|
Phase 4 | |
| Active, not recruiting |
NCT03646357 -
BEtablocker Treatment After Acute Myocardial Infarction in Patients Without Reduced Left Ventricular Systolic Function
|
Phase 4 | |
| Recruiting |
NCT05230446 -
PRospective Evaluation of Complete Revascularization in Patients With multiveSsel Disease Excluding chroNic Total Occlusions
|
N/A | |
| Completed |
NCT02983123 -
One-hour Troponin in a Low-prevalence Population of Acute Coronary Syndrome
|
||
| Recruiting |
NCT03541109 -
A Polypill for Secondary Prevention of Ischemic Heart Disease
|
Phase 3 | |
| Completed |
NCT03395041 -
Periodontal Disease, Inflammation and Acute Coronary Syndromes
|
||
| Recruiting |
NCT03863327 -
EKG Criteria and Identification of Acute Coronary Occlusion
|
||
| Completed |
NCT03389503 -
Comparison of Left and Right Transradial Approach for CAG and PCI
|
N/A | |
| Completed |
NCT03208153 -
the Invasive and Conservative Strategies in Elderly Frail Patients With Non-STEMI
|
N/A | |
| Completed |
NCT03690713 -
International Collaboration of Comprehensive Physiologic Assessment
|
||
| Completed |
NCT04161378 -
Impact of Cardiac Rehabilitation Programs on Left Ventricular Remodeling After Acute Myocardial Infarction - the REHAB Trial
|
||
| Recruiting |
NCT06040528 -
Early Discharge Pathway Registry
|
||
| Completed |
NCT03114995 -
Tailored Use of Tirofiban for Non-ST-elevation Acute Coronary Syndrome Patients
|
Phase 4 | |
| Recruiting |
NCT02900001 -
Routinely Deferred Versus Early Intervention in Elderly Patients With Non-ST-elevation Myocardial Infarction
|
N/A | |
| Recruiting |
NCT01555177 -
Study of Coronary Plaque Rupture in Heart Attack Following Surgery Using Optical Coherence Tomography (OCT)
|
N/A | |
| Not yet recruiting |
NCT05587621 -
Intensive Lipid-lowering in Patients With STEMI and NSTEMI (Germany on Target)
|
N/A | |
| Completed |
NCT03391908 -
Multiomics and Imaging-based Assessment of Vulnerable Coronary Plaques in Acute Coronary Syndromes
|