CBT for Patients With Attention Deficit Hyperactivity Disorder (ADHD) and Substance Use Disorders

Attention Deficit Hyperactivity Disorder Clinical Trial

Official title:

Investigating the Efficacy of Cognitive Behavioral Therapy in Patients With Substance Use Disorder and Comorbid ADHD. A Randomized Controlled Trial With Cognitive Behavioral Therapy

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01431235
• Other study ID #: 10-130
• Status: Completed
• Phase: N/A
• First received: September 8, 2011
• Last updated: January 13, 2017
• Start date: August 2011
• Est. completion date: December 2016

Study information

• Verified date: January 2017
• Source: Arkin
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to determine if cognitive behavioral therapy is effective in treating ADHD symptoms in patients with substance use disorders and comorbid ADHD.

Description:

Attention Deficit Hyperactivity Disorder(ADHD) is an important comorbid condition in patients with substance use disorders (SUD). The prevalence of ADHD in patients with SUD is estimated 23%, and ADHD is associated with an untoward prognosis of SUD. However, adequate treatment programs for patients with ADHD and SUD are not available. Results of medication trials for patients with ADHD and SUD are disappointing, and cognitive behavioral therapy (CBT) has not yet been investigated in this population. In patients with ADHD without comorbid SUD, the results of CBT in randomized trials are positive. The purpose of this study is to investigate if CBT is effective in treating ADHD symptoms in patients with ADHD and SUD.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 184
• Est. completion date: December 2016
• Est. primary completion date: December 2016
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 60 Years

Eligibility

Inclusion Criteria:

• substance use disorder

• ADHD

• able to comply with study activities

Exclusion Criteria:

• severe neurological or psychiatric diseases (for example Parkinson, dementia, psychosis, bipolar depression) which require medication

• unable to read or write Dutch language

Related Conditions & MeSH terms

• Attention Deficit Disorder with Hyperactivity
• Attention Deficit Hyperactivity Disorder
• Disease
• Hyperkinesis
• Substance Use Disorders
• Substance-Related Disorders

Intervention

Behavioral:
• cognitive behavioral therapy for treating ADHD symptoms
5 sessions of one hour CBT for treating ADHD symptoms by a trained health care worker

Locations

Country	Name	City	State
Netherlands	Arkin	Amsterdam

Sponsors (2)

Lead Sponsor	Collaborator
Arkin	Fonds NutsOhra

Country where clinical trial is conducted

Netherlands, 

References & Publications (4)

Arias AJ, Gelernter J, Chan G, Weiss RD, Brady KT, Farrer L, Kranzler HR. Correlates of co-occurring ADHD in drug-dependent subjects: prevalence and features of substance dependence and psychiatric disorders. Addict Behav. 2008 Sep;33(9):1199-207. doi: 10.1016/j.addbeh.2008.05.003. — View Citation

Castells X, Ramos-Quiroga JA, Rigau D, Bosch R, Nogueira M, Vidal X, Casas M. Efficacy of methylphenidate for adults with attention-deficit hyperactivity disorder: a meta-regression analysis. CNS Drugs. 2011 Feb;25(2):157-69. doi: 10.2165/11539440-000000000-00000. — View Citation

Safren SA, Sprich S, Mimiaga MJ, Surman C, Knouse L, Groves M, Otto MW. Cognitive behavioral therapy vs relaxation with educational support for medication-treated adults with ADHD and persistent symptoms: a randomized controlled trial. JAMA. 2010 Aug 25;304(8):875-80. doi: 10.1001/jama.2010.1192. — View Citation

Solanto MV, Marks DJ, Wasserstein J, Mitchell K, Abikoff H, Alvir JM, Kofman MD. Efficacy of meta-cognitive therapy for adult ADHD. Am J Psychiatry. 2010 Aug;167(8):958-68. doi: 10.1176/appi.ajp.2009.09081123. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	self reported ADHD symptoms	Dutch self report list of ADHD symptoms by Kooij and Buitelaar	6 months
Secondary	Time Line Follow Back method	self-reported alcohol and drug use	6 months
Secondary	Beck depression inventory	self reported depression symptoms	6 months
Secondary	Beck Anxiety Inventory	Self reported anxiety symptoms	6 months
Secondary	EQ-5	Self reported quality of living	6 months
Secondary	TIC-P	health care consumption and production loss in relation to mental health problems	6 months
Secondary	Stroop task	neuropsychological measure	6 months
Secondary	Tower of London task	neuropsychological task	6 months
Secondary	BART task	neuropsychological task on risk taking behavior	6 months
Secondary	urine checks	urine checks on drug use	6 months