Idiopathic Interstitial Pneumonias Clinical Trial
Official title:
Genetics, Genomics, and Proteomics of Idiopathic Interstitial Pneumonias: Identification of Susceptibility Genes, Biomarkers, and Molecular Phenotyping
We hypothesize that a peripheral blood biomarker or biological signature (gene or protein expression pattern) of idiopathic interstitial pneumonias (IIPs) will simplify and improve the accuracy of diagnosis of IIP and diagnose individuals at an earlier, more treatable, stage of their disease.
The Broad Challenge Area addressed in this proposal is (03) Biomarker Discovery and
Validation, and the Specific Challenge Topic is 03-HL-101 (Identify and validate clinically
relevant, quantifiable biomarkers of diagnostic and therapeutic responses for blood,
vascular, cardiac, and respiratory tract dysfunction). Idiopathic interstitial pneumonia
(IIP) is a lung disease(s) that primarily affects the elderly, but is present in all age
groups. IIP causes respiratory insufficiency and is often fatal. In about half of the
patients, the diagnosis requires an invasive lung biopsy which can cause complications, and
is not always accurate.
The current diagnostic tools for IIP are inadequate. In addition to inaccurate diagnosis,
they are very costly, and often result in delayed diagnosis and treatment. The challenge(s)
we intend to address in this proposal is to improve the accurate and early diagnosis of
idiopathic interstitial lung pneumonia (IIP), and to improve the ability to differentiate
the subtypes of idiopathic interstitial pneumonias (IIPs) by developing peripheral blood
biomarkers.
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Observational Model: Case Control, Time Perspective: Cross-Sectional
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