Inflammatory Response During Cardiac Surgery Clinical Trial
Official title:
Changes in Leukotrienes During Cardiac Surgery in Patients With Chronic Obstructive Pulmonary Disease
Verified date | March 2013 |
Source | Massachusetts General Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | United States: Institutional Review Board |
Study type | Observational |
The hypotheses of this study are that:
- Production and release of inflammatory substances called leukotrienes are increased
during heart surgery with use of a heart-lung machine in humans;
- The increase in these leukotrienes levels after heart surgery is higher in patients
with bronchitis and/or emphysema than in patients without previous history of lung
disease;
- Levels of leukotrienes are directly correlated with worsening of lung function during
and after heart surgery.
Status | Completed |
Enrollment | 20 |
Est. completion date | December 2010 |
Est. primary completion date | December 2010 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Adult patients schedules to undergo cardiac surgery with use of CPB. Exclusion Criteria: - inability to provide consent; - previous diagnosis of asthma; - acute pre-operative respiratory failure; - emergency surgery. |
Observational Model: Case Control, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Massachusetts General Hospital | Merck Sharp & Dohme Corp. |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | urine cysteinyl leukotriene | intra-operative | No |