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Clinical Trial Summary

This is a single-center, single-arm, open-label phase I clinical study to determine the safety and efficacy of LILRB4 STAR-T cells in Relapsed/Refractory Acute Myeloid Leukemia subjects.


Clinical Trial Description

This study will recruit LILRB4 positive AML subjects,and Subjects will receive cytoreductive chemotherapy with cyclophosphamide and fludarabine on days -5, -4 and -3 followed by infusion of LILRB4 STAR-T cells. LILRB4 STAR-T cells will be intravenously infused with a escalated dose of 1E6、3E6、6E6、1E7 cells/kg.The purpose of current study is to evaluate the clinical safety and tolerability of LILRB4 STAR-T cells therapy in patients with refractory and relapsed AML.Safety and efficacy of LILRB4 STAR-T cells therapy will be monitored.The primary endpoint of the study is to observe DLT, AE, SAE, CRS and ICANS. Secondary objectives are to observe the efficacy of LILRB4 STAR-T cells, including RFS, EFS and OS, and PK. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05548088
Study type Interventional
Source Peking University People's Hospital
Contact Xiangyu Zhao
Phone 010-88325949
Email zhao_xy@bjmu.edu.cn
Status Not yet recruiting
Phase Phase 1
Start date November 30, 2022
Completion date August 30, 2024

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