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Acute Lymphoblastic Leukemia Treatment Protocol Moscow-Berlin 2019 Pilot

Childhood Acute Lymphoblastic Leukemia Clinical Trial

Official title:
Treatment of Children and Adolescents With Primary B-precursor Acute Lymphoblastic Leukemia With Combination Chemotherapy and Immunotherapy

Clinical Trial Summary

THE PURPOSE OF THE STUDY is to optimize the therapy of patients with primary B-cell precursor acute lymphoblastic leukemia (BCP-ALL) by including monoclonal bispecific antibodies in post-induction treatment with simultaneous reduction of chemotherapy. QUESTIONS AND OBJECTIVES OF THE STUDY: - to determine the efficacy and feasibility of chemotherapy and immunotherapy combination in comparison with standard PCT in children and adolescents with newly diagnosed BCP-ALL; - to determine the safety and toxicity of chemotherapy and immunotherapy combination in comparison with standard PCT in children and adolescents with newly diagnosed BCP-ALL; - to determine the possibility of chemotherapy reducing when immunotherapy is included in the treatment regimen without loss of effectiveness; - to determine the possibility of reducing the maintenance therapy duration to 1 year when immunotherapy is included in the treatment regimen without loss of effectiveness.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04723342
Study type Interventional
Source Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Contact Alexander I. Karachunskiy, Professor,MD
Phone +7-926-218-84-09
Email info@mbstudy.net
Status Recruiting
Phase N/A
Start date February 1, 2020
Completion date December 2025
View Details
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