Chronic Graft-versus-host Disease Clinical Trial
Official title:
Mesenchymal Stem Cell for Treatment of Chronic Graft-versus-host Disease After Allogenetic Hematopoietic Stem Cell Transplantation
The purpose of this study is to evaluate the efficacy of mesenchymal stem cells in patients with chronic graft-versus-host disease.
Allogeneic hematopoietic stem cell transplantation(allo-HSCT) can cure many hematologic diseases. Although great progress has been made in the prevention and treatment of side effects associated with transplantation,chronic graft-versus-host disease(cGVHD) remains an important complication that occurs in about 50% patients. The mortality of cGVHD and its complication could reach up to 50%,and cGVHD seriously influence the quality of life. At present, the first line treatment of cGVHD remains in discussion. Mesenchymal stem cells (MSCs) are a form of multipotent adult stem cells that can be isolated from bone marrow (BM), adipose tissue, and cord blood. Clinical applications of human MSCs are evolving rapidly with goals of improving hematopoietic engraftment, preventing and treating GVHD after allo-HSCT and so on. However, the efficacy of treatment of cGVHD remains undetermined. In the present study, the investigators will prospectively evaluate the efficacy and safety of ex-vivo-expanded MSCs in treating patients with cGVHD. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02991846 -
A Prospective Observational Study for Evaluating CGVHD
|
||
| Recruiting |
NCT02291770 -
Treatment of Chronic Graft-Versus-Host Disease With Mesenchymal Stromal Cells
|
Phase 3 | |
| Terminated |
NCT01226420 -
Alefacept in Subjects With Steroid-Refractory Chronic Graft-versus-Host Disease
|
Phase 2 | |
| Active, not recruiting |
NCT02759731 -
Study of Baricitinib, a JAK1/2 Inhibitor, in Chronic Graft-Versus-Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation
|
Phase 1/Phase 2 | |
| Completed |
NCT01862965 -
Treatment of Newly Diagnosed Moderate or Severe Chronic Graft-versus-host Disease With Prednisone and Everolimus
|
Phase 2 | |
| Completed |
NCT02411474 -
Tear Cytokine Analysis as a Prediction or Diagnostic Marker in Ocular GvHD
|
N/A | |
| Completed |
NCT02040623 -
Safety and Efficacy Study of R932348 Ophthalmic Solution in Chronic Ocular Graft Versus Host Disease Patients(DROPS-2)
|
Phase 2 | |
| Active, not recruiting |
NCT01158105 -
Bortezomib for the Treatment of Refractory Chronic Graft-vs-Host Disease(cGVHD)
|
Phase 2 | |
| Terminated |
NCT01903473 -
Donor Regulatory T Cells Infusion in Patients With Chronic Graft-versus-host Disease (GVHD)
|
Phase 2 | |
| Active, not recruiting |
NCT01366092 -
Daily IL-2 for Steroid-Refractory Chronic Graft-versus-Host-Disease
|
Phase 2 | |
| Recruiting |
NCT05690971 -
Psychosocial Mobile App for Chronic Graft-Versus-Host Disease
|
N/A | |
| Recruiting |
NCT02918188 -
Therapeutic Effects of Hydrogen on Steroid-refractory/or Steroid-dependent cGVHD
|
Phase 2 | |
| Recruiting |
NCT01765660 -
Mesenchymal Stem Cells for Treatment of Refractory Chronic Graft-versus-host Disease
|
Phase 2 | |
| Completed |
NCT01956903 -
Treatment of Refractory Acute Graft-Versus-Host Disease by Sequential Infusion of Allogenic Mesenchymal Stem Cell.
|
Phase 1/Phase 2 | |
| Terminated |
NCT03584516 -
GRAVITAS-309: Itacitinib and Corticosteroids as Initial Treatment for Chronic Graft-Versus-Host Disease
|
Phase 2/Phase 3 | |
| Completed |
NCT02966301 -
Treatment of Chronic Graft Versus Host Disease With Arsenic Trioxide
|
Phase 2 | |
| Terminated |
NCT01898377 -
Imatinib Mesylate and Mycophenolate Mofetil for Steroid-Refractory Sclerotic/Fibrotic cGVHD in Children
|
Phase 2 | |
| Recruiting |
NCT02611180 -
Dendritic Cells in Patients With Acute or Chronic Skin Graft Versus Host Disease
|
||
| Recruiting |
NCT02669251 -
Alvelestat (MPH966), an Oral Neutrophil Elastase Inhibitor, in Bronchiolitis Obliterans Syndrome After Allogeneic Hematopoietic Stem Cell Transplantation
|
Phase 1/Phase 2 | |
| Active, not recruiting |
NCT01161628 -
Rituximab for the Primary Treatment of Denovo Extensive Chronic Graft Versus Host Disease (GVHD)
|
Phase 2 |