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Treatment of Chronic Graft-Versus-Host Disease With Mesenchymal Stromal Cells — MSC-cGvHD  

Chronic Graft-Versus-Host Disease Clinical Trial

Official title:
Treatment of of Chronic Graft-Versus-Host Disease With Mesenchymal Stromal Cells. A Phase III Randomized Open Label Multi-center Study in Southern China.

Clinical Trial Summary

Chronic Graft-versus-Host Disease (cGvHD) is a potentially lethal disorder. A variety of second line immunosuppressive agents have been investigated but no optimal treatment has emerged. There is therefore a need for novel treatment strategies. Mesenchymal stromal cells (MSC) exhibit immunomodulatory properties and a recent pilot study suggests a response rate of 70% in steroid- refractory patients. In the present randomized study the efficacy and safety of MSC treatment will be further studied in patients with cGvHD.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02291770
Study type Interventional
Source Guangdong General Hospital
Contact Xin Du, Prof.
Phone +86 02083827812-62122
Email miyadu@hotmail.com
Status Recruiting
Phase Phase 3
Start date October 2014
Completion date December 2019
View Details
See also
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