Treatment-resistant Schizophrenia Clinical Trial
Official title:
Sequential Multiple-Assignment Randomized Trials to Compare Antipsychotic Treatments in Treatment-Resistant Schizophrenia
The project intends to take treatment-resistant schizophrenia as the research object and uses sequential multiple assignment randomized trial(SMART) design to define the treatment recommendations of different drug regimen for treatment resistant schizophrenia and to determine the physical enhancement regimen for clozapine-resistant schizophrenia and to explore targeted regulation scheme for ultra-resistant schizophrenia.
This trial is a sequential multiple-assignment RCT design of antipsychotic drugs, planning to recruit 162 people with treatment-resistant schizophrenia followed for 12 months. The study includes three treatment phases and a naturalistic follow-up phase. Participants who meet the response criteria remain on that treatment for the duration of 12-month treatment. If the participants fail the treatment or can't tolerant the side effects, the patient moves to the next phase of the study to receive a new treatment. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
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Neural Biomarkers of Clozapine Response
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| Completed |
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Virtual Reality Therapy for Treatment-resistant Auditory Hallucinations in Schizophrenia
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N/A | |
| Completed |
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Early Phase 1 | |
| Not yet recruiting |
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Phase 4 | |
| Recruiting |
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N/A | |
| Completed |
NCT01105481 -
Amisulpride Augmentation Therapy for Clozapine-resistant Schizophrenic Patients
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Phase 4 | |
| Recruiting |
NCT02361554 -
Deep Brain Stimulation in Treatment Resistant Schizophrenia
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N/A | |
| Recruiting |
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Real-time fMRI Neurofeedback in Patients With Schizophrenia and Auditory Hallucinations
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N/A | |
| Completed |
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Avatar Therapy in Comparison to Cognitive Behavioral Therapy for Treatment-resistant Schizophrenia
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N/A | |
| Not yet recruiting |
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Low-Intensity Focused Ultrasound Neuromodulation of the Mediodorsal Thalamus for Treatment-Resistant Schizophrenia
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N/A | |
| Terminated |
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Efficacy of Lu AF35700 in Patients With Early-in-disease or Late-in-disease Treatment-resistant Schizophrenia
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Phase 3 | |
| Recruiting |
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Deep Brain Stimulation Recovery in Treatment-Resistant Schizophrenia
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N/A | |
| Terminated |
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Telmisartan Pilot Study on Treatment Resistant Schizophrenia
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Phase 2 | |
| Not yet recruiting |
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The Characteristics of Treatment Resistant Schizophrenia From the Illness Onset
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| Recruiting |
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| Completed |
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Rituximab for Schizophrenia Spectrum Disorder (RITS-PS-2019)
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Phase 1 | |
| Recruiting |
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Phase 4 | |
| Recruiting |
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|
N/A |