Clinical Trial Details
— Status: Completed
Administrative data
NCT number |
NCT04325230 |
Other study ID # |
CHUBX 2020/01 |
Secondary ID |
|
Status |
Completed |
Phase |
N/A
|
First received |
|
Last updated |
|
Start date |
May 17, 2020 |
Est. completion date |
January 12, 2023 |
Study information
Verified date |
April 2023 |
Source |
University Hospital, Bordeaux |
Contact |
n/a |
Is FDA regulated |
No |
Health authority |
|
Study type |
Interventional
|
Clinical Trial Summary
The main purpose of this study will be to evaluate the prognostic value at 3 months of life
of brain perfusion MRI determined by Arterial Spin Labeling technique in the first week of
life of term newborns with hypoxic-ischemic encephalopathy requiring management in neonatal
intensive care unit.
Description:
Hypoxic-ischemic encephalopathy is the result of birth asphyxia due to transitory cerebral
blood flow drop during perinatal period. It is the leading cause of neonatal encephalopathy,
and thus a major cause of perinatal mortality, morbidity and adverse neurodevelopmental
outcome. Usual care brain MRI is critically important in the diagnosis and prognosis. Lasting
about 30 to 40 minutes, MRI exam includes successive sequences providing complementary
information but none relatively to brain perfusion. Perfusion MRI without contrast media
injection is possible using Arterial Spin Labeling (ASL) sequence. ASL is highly suitable for
neonates, noninvasiveness, and lasts only 5 minutes. However, only one study assessed ASL as
a prognostic factor. The purpose of the study is therefore to perform ASL sequence within
usual care brain MRI.