ST Segment Elevation Myocardial Infarction Clinical Trial
Official title:
EARLY Microvascular Dysfunction Assessment Using Quantitative Flow Ratio After ST-segment Elevation MYOcardial Infarction (EARLY-MYO-QFR II)
The study intends to provide new data on whether the noval method using quantitative flow ratio could assess microvascular dysfunction based on the previous study EARLY-MYO-QFR-I.
Microvascular dysfunction (MVD) is a serious complication of PCI, which happens frequently
after STEMI and always correlates with a poor prognosis. However, precise and simplified
assessment of MVD is difficult, especially in the acute phase of STEMI patients. Resent
studies suggested that FFR could be overestimated when MVD exists. But whether the
overestimated value of FFR caused by CMR defined microvascular obstruction (MVO) could
reflect microvascular function is still unclear.
In the previous study EARLY-MYO-QFR-I, we have demonstrated that the relationship between
Contrast-enhanced CMR defined MVO and QFR. While angiography images were collected on a
retrospectively manner, and the study population were selected (STEMI patients with
spontaneously recanalized culprit vessel before PCI) to verify our hypothesis.
This phase of study would be a prospective study. We tend to created a new study population
by a temporary artificial stenosis inside the stent by partially inflating a balloon catheter
during pharmacologic hyperemia in STEMI patients.
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