Split Renal Function Using 99mTc-DTPA Versus 99mTc-DMSA in Kidney Patients of Wide Age Ranges.

The Difference in Estimation of Split Renal Function Using the Two Radiopharmaceuticals:Tc-99m DTPA & Tc-99m DMSA in Kidney Patients Clinical Trial

Official title:

Split Renal Function Using 99mTc-DTPA Versus 99mTc-DMSA in Kidney Patients of Wide Age Ranges

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT03879005
• Other study ID #: SRF using DTPA Vs DMSA
• Status: Not yet recruiting
• Phase: N/A
• Start date: April 2019
• Est. completion date: October 2019

Study information

• Verified date: March 2019
• Source: Assiut University
• Contact: Marwa F Abd El Hay
• Phone: 0102291658
• Email: f.marwa1992[@]gmail.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

To evaluate split renal function using Tc-99m DTPA versus Tc-99m DMSA.

Description:

Split renal function (SPR) is a determination of the relative contribution of each of the two kidneys . It gives a useful information in several conditions such as evaluating unilateral renal disorders, assessing individual kidney function before and after intervention, and before live donor nephrectomy. Different radiopharmaceuticals such as technetium‐99m dimercaptosuccinic acid (99mTc‐DMSA), technetium‐99m diethylenetriaminepentaaceticacid (99mTc‐DTPA), technetium‐99m mercaptoacetyltriglycine (99mTc‐MAG3), Iodine 131 orthoiodohippurate and more recently technetium‐99 m ethylenedicysteine (99mTc‐EC) were used, However, 99mTc‑DMSA as a static renal agent is considered the most reliable method to measure relative renal function and the most appropriate tracer for renal cortical imaging . In some papers, it is emphasized that relative renal function calculated with 99mTc‑DTPA is as reliable as 99mTc‑DMSA .‬ The investigators design the study to evaluate the difference in estimation of split renal function using the available two radiopharmaceuticals: Tc-99m DTPA and Tc-99m DMSA.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 25
• Est. completion date: October 2019
• Est. primary completion date: September 2019
• Accepts healthy volunteers: No
• Gender: All
• Age group: 2 Months to 80 Years

Eligibility

Inclusion Criteria:

1. Kidney patients of wide age ranges.

2. Patients with renal disorders who referred for DMSA and DTPA split renal function.

3. Patients able to sleep in a fixed position for 20 minutes.

Exclusion Criteria:

1. Children unable to sit calm without movement during imaging.

2. Severely ill patients.

3. Patients with allergy to one or more of material method.

Related Conditions & MeSH terms

• The Difference in Estimation of Split Renal Function Using the Two Radiopharmaceuticals:Tc-99m DTPA & Tc-99m DMSA in Kidney Patients

Intervention

Other:
• renal scintigraphy
99mTc-DTPA Scintigraphy Five mci of 99mTc-DTPA will be injected by IV route together with diuretic. Dose will be adjusted according to the age and weight of the patients. A total of 20 min dynamic imaging followed by calculation of GFR and SRF according to the built-in processing protocol Gate's method. 99mTc-DMSA scintigraphy Five mci of 99mTc- DMSA will be injected by IV route with adjustment according to age and weight. Static images will be acquired in the posterior, anterior, andposterior oblique projections for 60 s each.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Assiut University

References & Publications (4)

Ardela Díaz E, Miguel Martínez B, Gutiérrez Dueñas JM, Díez Pascual R, García Arcal D, Domínguez Vallejo FJ. [Comparative study of differential renal function by DMSA and MAG-3 in congenital unilateral uropathies]. Cir Pediatr. 2002 Jul;15(3):118-21. Span — View Citation

Cao X, Xu X, Grant FD, Treves ST. Estimation of Split Renal Function With (99m)Tc-DMSA SPECT: Comparison Between 3D Volumetric Assessment and 2D Coronal Projection Imaging. AJR Am J Roentgenol. 2016 Dec;207(6):1324-1328. Epub 2016 Sep 13. — View Citation

Çelik T, Yalçin H, Günay EC, Özen A, Özer C. Comparison of the Relative Renal Function Calculated with 99mTc-Diethylenetriaminepentaacetic Acid and 99mTc-Dimercaptosuccinic Acid in Children. World J Nucl Med. 2014 Sep;13(3):149-53. doi: 10.4103/1450-1147. — View Citation

Lee WG, Kim JH, Kim JM, Shim KM, Kang SS, Chae HI, Choi SH. Renal uptakes of 99mTc-MAG3, 99mTc-DTPA, and 99mTc-DMSA in rabbits with unilateral ureteral obstruction. In Vivo. 2010 Mar-Apr;24(2):137-9. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Split renal function using 99mTc-DTPA versus 99mTc-DMSA in kidney patients of wide age ranges.	To emphasize that split renal function calculated with Tc-99m DTPA is as reliable as Tc-99m DMSA	one year