The Difference in Estimation of Split Renal Function Using the Two Radiopharmaceuticals:Tc-99m DTPA & Tc-99m DMSA in Kidney Patients Clinical Trial
Official title:
Split Renal Function Using 99mTc-DTPA Versus 99mTc-DMSA in Kidney Patients of Wide Age Ranges
To evaluate split renal function using Tc-99m DTPA versus Tc-99m DMSA.
Split renal function (SPR) is a determination of the relative contribution of each of the two kidneys . It gives a useful information in several conditions such as evaluating unilateral renal disorders, assessing individual kidney function before and after intervention, and before live donor nephrectomy. Different radiopharmaceuticals such as technetium‐99m dimercaptosuccinic acid (99mTc‐DMSA), technetium‐99m diethylenetriaminepentaaceticacid (99mTc‐DTPA), technetium‐99m mercaptoacetyltriglycine (99mTc‐MAG3), Iodine 131 orthoiodohippurate and more recently technetium‐99 m ethylenedicysteine (99mTc‐EC) were used, However, 99mTc‑DMSA as a static renal agent is considered the most reliable method to measure relative renal function and the most appropriate tracer for renal cortical imaging . In some papers, it is emphasized that relative renal function calculated with 99mTc‑DTPA is as reliable as 99mTc‑DMSA . The investigators design the study to evaluate the difference in estimation of split renal function using the available two radiopharmaceuticals: Tc-99m DTPA and Tc-99m DMSA. ;