Efficacy and Safety of DBS in Patients With Treatment-Resistant Depression

Treatment Resistant Depressive Disorder Clinical Trial

Official title: Efficacy and Safety of MRI Compatible and Long-term LFP Recordable Deep Brain Stimulation in Patients With Treatment-Resistant Depression

Status Not yet recruiting

Clinical Trial Summary

The habenula (Hb) is an ancient structure, located at the center of the dorsal diencephalic conduction system, a pathway involved in linking forebrain to midbrain regions. An increasing number of studies indicated that the lateral habeluna (LHb) is overactivity during depressive behaviors in rats, where it could drive the changes in midbrain monoamine neurotransmitter linked to depression. However, the efficiency and mechanism of deep brain stimulation (DBS) of the LHb and/or its major afferent bundle (i.e., stria medullaris thalami) could treat treatment-resistant major depression (TRD) is still unclear. This research will investigate the effectiveness and mechanism of bilateral MRI Compatible and Long-term LFP Recordable DBS to habenula and/or its major afferent bundle for treatment TRD patients.

Clinical Trial Description

n/a

Related Conditions & MeSH terms

• Depression
• Depressive Disorder
• Depressive Disorder, Treatment-Resistant
• Treatment Resistant Depressive Disorder

• NCT number: NCT03667872
• Study type: Interventional
• Source: Beijing Pins Medical Co., Ltd
• Contact: Zhiyan Wang
• Phone: 010-60736388
• Email: wzyann@126.com
• Status: Not yet recruiting
• Phase: N/A
• Start date: January 15, 2019
• Completion date: June 18, 2022