Exacerbation of Idiopathic Pulmonary Fibrosis Clinical Trial
Official title:
Therapeutic Plasma Exchange, Rituximab and Intravenous Immunoglobulins for Severe Acute Exacerbation of Idiopathic Pulmonary Fibrosis Admitted in ICU: an Open, Randomized, Controlled Trial
Idiopathic pulmonary fibrosis (IPF) is a fibroproliferative, irreversible disease of unknown cause, occurring mainly in patients older than 50. IPF is a rare but fatal lung disease, with an estimated prevalence of 14 to 28/100000 and a median survival time of 3 years. Acute exacerbation of IPF (AE-IPF) is a major event of IPF, as it is responsible for the death of 30-50 % of IPF patients; its annual incidence varies between 5 and 10%. The current literature indicates that IPF is associated with the development of an auto-immunity process targeting epithelial and endothelial lung cells. Autoantibodies have been associated with a poorer prognosis. A study by DONAHOE et al. (Plos One, 2015) indicates that the combination of corticosteroids, plasma exchanges, rituximab and immunoglobulins may improve the prognosis of the most severe forms of AE-IPF. In that study, the observed survival rate in patients receiving this combination of treatment was 70% as compared with 20% in historical controls. This therapeutic combination approach is designed both to eliminate and inhibit the production of circulating antibodies targeting the lungs. Considering the high mortality rate of an AE-IPF episode and the potential benefit of such an original approach, a well-conducted randomized controlled trial is critical.
Idiopathic pulmonary fibrosis (IPF) is a fibroproliferative, irreversible disease of unknown
cause, occurring mainly in patients older than 50. IPF is a rare but fatal lung disease, with
an estimated prevalence of 14 to 28/100000 and a median survival time of 3 years. Acute
exacerbation of IPF (AE-IPF) is a major event of IPF, as it is responsible for the death of
30-50 % of IPF patients; its annual incidence varies between 5 and 10%. The current
literature indicates that IPF is associated with the development of an auto-immunity process
targeting epithelial and endothelial lung cells. Autoantibodies have been associated with a
poorer prognosis. A study by DONAHOE et al. (Plos One, 2015) indicates that the combination
of corticosteroids, plasma exchanges, rituximab and immunoglobulins may improve the prognosis
of the most severe forms of AE-IPF. In that study, the observed survival rate in patients
receiving this combination of treatment was 70% as compared with 20% in historical controls.
This therapeutic combination approach is designed both to eliminate and inhibit the
production of circulating antibodies targeting the lungs. Considering the high mortality rate
of an AE-IPF episode and the potential benefit of such an original approach, a well-conducted
randomized controlled trial is critical.
The main objective is to evaluate the impact on overall mortality at day 28 of plasma
exchanges, rituximab, intravenous immunoglobulins (IVIg), and corticosteroid administration
versus standard corticosteroid therapy in hypoxemic patients admitted in ICU for severe acute
exacerbation of idiopathic pulmonary fibrosis.
The primary assessment criterion will be overall mortality at day 28 after initiation of
therapy (Day 1).
Secondary objectives are the following:
1. Efficacy:
1.1. To compare the overall mortality at day 90, at 6 months and at 12 months after the
initiation of therapy 1.2. To compare the exposition to mechanical ventilation 1.3. To
compare the length of ICU and hospital-stay 1.4. To compare the evolution of Sequential
Organ Failure Assessment (SOFA) score 1.5. To compare the radiological evolution 1.6. To
compare the evolution of lung injury biomarkers in plasma 1.7. To compare the changes in
circulating autoantibodies levels before and after therapy 1.8. To compare the evolution
of blood fibrocytes proportion 1.9. To evaluate respiratory functional at 3 months and
compare data previously available.
1.10. To assess quality of life (SF36), autonomy (ADL) and muscle strength scores (MRC)
at 3 months of inclusion (Cf annexe)
2. Safety:
2.1. To compare the occurrence of healthcare-associated infection 2.2. To describe the
specific complications associated to the experimental treatment
Secondary assessment criteria are the following:
3. Efficacy:
3.1. Overall mortality at day 90, at 6 months and at 12 months 3.2. Number of days alive
without mechanical ventilation between inclusion and day 28 3.3. Length of ICU-stay and
hospital-stay 3.4. Changes in SOFA score from D1 to D3, D7, D16, D21, D28 or
discharge-day from ICU as appropriate 3.5. Variation of global extent of High Resolution
Computed Tomography (HRCT) infiltrates between initial HRCT and D90 3.6. Changes in lung
injury plasmatic biomarkers (KL-6, SP-D) from D1 to D16, D21, D28 and D90 3.7. Changes
in circulating antibodies levels (anti-periplakin, anti-HSP70 and anti-vimentin
antibodies) from D1 to D28 and D90 3.8. Changes in the proportion of blood fibrocytes
from D1 to D16, D28 and D90
4. Safety:
4.1. Proportion of patients with at least one episode of any healthcare-associated infection
between inclusion and D28 4.2. The following complications in the experimental group will be
described: 4.2.1. Proportion of catheter-linked complications between inclusion and D16
4.2.2. Number of blood units transfused between inclusion and day 28. 4.2.3. Proportion of
major bleeding according to the International Society On Thrombosis And Haemostasis 4.2.4.
Proportion of patients with occurrence of an acute renal failure at D28, according to the
Kidney Disease Improving Global Outcomes (KDIGO) guidelines 4.2.5. Proportion of patients
with anaphylactic reaction at day 28
The experimental design is multicenter, randomized, controlled, open-label superiority trial
in parallel groups. The population involved is ICU patients with a Partial pressure of
oxygen/ Fraction inspired by oxygen (PaO2/FIO2) ratio < 200 and a diagnosis of acute
exacerbation of idiopathic pulmonary fibrosis.
The experimental group will receive a combination of:
1. Methylprednisolone bolus of 1g i.v. day 1, then 20 mg/day (or oral prednisone
equivalent) for 21 days;
2. Nine therapeutic plasma exchanges of 1.5x the estimated plasma volumes using
albumin:saline (3:1) or fresh frozen plasma in case of an International Normalised Ratio
(INR) superior to 1.5, on days 1,2,3,5,7,9,11,13,15; followed by administration of low
dose of intravenous immunoglobulin (100 mg/kg)
3. Rituximab 1 g i.v. on days 7 and 15 (after therapeutic plasma exchange and
premedication);
4. Intravenous immunoglobulin 0.5 g/kg/d on days 16 to 19.
The reference group will receive:
Intravenous methylprednisolone bolus of 10 mg/kg (max. 1g) on day 1, 2 and 3, then 1 mg/kg/d
for 1 week, and 0.75 mg/kg/d for 1 week, then 0.5 mg/kg/d for 1 week, and 0.25 mg/kg/d for 1
week, and 0.125 mg/kg/d until day 90. Shift to oral prednisone as soon as the oral route is
available.
Other procedures added by the research:
Blood sampling for serial serum lung injury biomarkers, fibrocytes determination and
circulating antibodies measurements
Risks added by the research: C Number of subjects chosen: 40 Number of centres : 17
Research period:
Inclusion period: 36months Length of participation: one year
- Maximum period between selection and inclusion: 3 days
- Treatment period: 90 days
- Follow up period: 1 year +/- 2 weeks
- Total research period: 48 months
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