Clinical Trial Details
— Status: No longer available
Administrative data
| NCT number |
NCT03386071 |
| Other study ID # |
17-001886 |
| Secondary ID |
Compassionate Us |
| Status |
No longer available |
| Phase |
|
| First received |
|
| Last updated |
|
Study information
| Verified date |
January 2019 |
| Source |
Jonsson Comprehensive Cancer Center |
| Contact |
n/a |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Expanded Access
|
Clinical Trial Summary
The dosage of trametinib for oral administration is 2mg once daily. The patient is instructed
to take the trametinib oncedaily dose at approximately the same time each day, by mouth with
approximately 200 mL (almost 1 cup) of water on an empty stomach, either 1 hour before or 2
hours after a meal.
Description:
The dosage of trametinib for oral administration is 2mg once daily. The patient is instructed
to take the trametinib once daily dose at approximately the same time each day, by mouth with
approximately 200 mL (almost 1 cup) of water on an empty stomach, either 1 hour before or 2
hours after a meal.
The patient will be provided with complete dosing instructions from his treating physician.
If the subject is instructed that if he vomits after taking either of the medications
provided under this program, he should not retake the dose. The patient should take the next
dose as originally scheduled. If a dose is missed, the patient should not double the next
regularly scheduled dose. However, the patient can take the missed dose immediately if the
next scheduled dose is at least 12 hours later. If the next scheduled dose is due in less
than 12 hours, the patient is instructed to skip the dose and resume dosing the next day at
the regular time. Then to take the next dose at the usual time the subject is scheduled to
take it. It is not known for how long the subject will remain in the program because each
patient may respond differently to the treatment. The length of time the patient will take
trametinib therapy will depend on his cancer status and how well he tolerates the drugs. If
he experiences severe side effects, he is instructed to call his treating physician
immediately. The treating physician may advise him stop compassionate used of trametinib or
may advise him to lower the dose. Trametinib may also be stopped completely at his Treating
Physician's discretion. The treating physician will use his/her clinical expertise
considering the intensity of the adverse effect and/or the results of your laboratory tests
to make his/her decision. The Treating Physician may consult with the Novartis Country Pharma
Organization Medical Advisor/Director about dose interruptions or modifications.
