Chronic Obstructive Pulmonary Disease Clinical Trial
Official title:
Effects of Lumbar Transcutaneous Electrical Nerve Stimulation on Exercise Performance in Patients With Chronic Obstructive Pulmonary Disease : A Pilot Study
Chronic obstructive pulmonary disease is a leading cause of morbidity and mortality
worldwide.
Pulmonary rehabilitation effectively improves outcomes in patients with chronic respiratory
disease. There is a link between training intensity and physiological improvements following
pulmonary rehabilitation. However, high intensity training is not sustainable for every
patients.
Therefore, actual strategies for pulmonary rehabilitation aimed at decreasing dyspnea to
improve muscle work.
Electrical muscle stimulation is widely used during rehabilitation to promote muscle function
recovery. Transcutaneous electrical nerve stimulation was recently used to relief dyspnea and
improve pulmonary function in patients with chronic respiratory disease. Moreover, spinal
anesthesia with fentanyl has been shown to be effective in improving exercise tolerance in
patients with chronic obstructive pulmonary disease (inhibiting group III and IV muscle
afferents). As transcutaneous electrical muscle stimulation stimulates the same receptors in
the spinal cord dorsal horn as fentanyl, it is hypothesized that it could also improve
exercise capacity.
Therefore, the aim of this study is to assess wether transcutaneous electrical stimulation
(high or low frequency) is effective in improving exercise capacity in patients with severe
to very severe chronic obstructive pulmonary disease.
Design : cross-over.
Patients will perform three constant workload testing (CWT) on different days under three
different conditions. The intervention during the tests will be randomly assigned (concealed
allocation) :
- Sham transcutaneous electrical nerve stimulation ;
- High-frequency transcutaneous electrical nerve stimulation ;
- Low-frequency transcutaneous electrical nerve stimulation.
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