Drug Induced Tardive Syndrome (DITS) Clinical Trial
Official title:
First Repetitive Transcranial Magnetic Stimulation for Treatment of Drug Induced Tardive Syndromes. Double Randomized Clinical Trial
This study aims to evaluate the efficacy of rTMS on DITS. Twenty patients with DITS were recruited from the outpatient clinic of Aswan University Hospital. The patients were classified into two equal groups, 1st group received real high frequency rTMS at 100% RMT and the 2nd group received sham stimulation with the same pulse delivery but with the coil placed perpendicular to the scalp. For each patient 10 sessions were administered once per day for 5 consecutive days each week for two weeks. All patients were assessed before rTMS and immediately after the end of the 10 sessions. This study is double blinded (the doctor and the patients). Assessment with AIMS scale and different parameters of cortical excitability were performed before and after the end of sessions treatment.
The aim of this study was to evaluate the efficacy of repetitive transcranial magnetic
stimulation (rTMS) on drug induced tardive syndromes.
the effect of rTMS compare. Twenty patients with drug induced tardive syndromes were
recruited from the outpatient clinic of Aswan University Hospital. The patients were
classified into two equal groups, 1st group received real 20 Hz-rTMS at 100% RMT (a total of
2000 pulses to each hand area consisting of 10 trains of 200 pulses with intertrain interval
30 s), and the 2nd group received sham stimulation with the same pulse delivery as the 1st
group but with the coil placed perpendicular to the scalp. For each patient 10 sessions were
administered once per day for 5 consecutive days each week for two weeks. All patients were
assessed before rTMS and immediately after the end of the 10 sessions. The patients did not
know which type of stimulation they received and to ensure that, the study was double blinded
the doctor who assessed the patients didn't know which type of stimulation the patients
received. None of the patients had had rTMS before and were unaware of the type of
stimulation.The AIMS scale and different parameters of cortical excitability were assessed
before and after the end of session treatment.
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