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Effect of Chronic Exenatide Therapy on Beta Cell Function and Insulin Sensitivity in T2DM

Diabetes Mellitus, Type 2 Clinical Trial

Official title:
Effect of Chronic Exenatide Therapy on Beta Cell Function and Insulin Sensitivity in Type 2 Diabetes Mellitus (T2DM)

Clinical Trial Summary

In this study, the researchers hope to learn about SGLT2 inhibition on EGP (endogenous glucose production) and plasma glucose concentration in diabetic subjects. Researchers will examine diabetes and the role of increased plasma glucagon, decline in plasma insulin, and fall in plasma glucose concentration.

Clinical Trial Description

This study will examine whether the coadministration of exenatide plus dapagliflozin will prevent the increase in EGP and result in an additive or even synergistic decrease in plasma glucose concentration compared to each agent alone. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02981069
Study type Interventional
Source The University of Texas Health Science Center at San Antonio
Contact
Status Completed
Phase Phase 4
Start date December 15, 2017
Completion date March 19, 2023
View Details
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