Diabetes Mellitus, Type 2 Clinical Trial
Official title:
Cardiac Magnetic Resonance Imaging in Type 2 Diabetes Mellitus: The Mechanisms of Cardiac Function and Perfusion Dysfunction
The study will be performed as a cross-sectional survey. 300 Type 2 diabetes patients (T2DM),
with or without known cardiovascular disease, will be recruited from the diabetes outpatient
clinic, Slagelse Hospital. The patients will undergo echocardiography, Cardiac magnetic
resonance imaging (CMR), clinical examination and will be asked to fill out questionnaires.
This study project sets out to answer the following hypotheses:
1. Patients with T2DM have an increased risk of developing diastolic dysfunction. Using
CMR, the investigators wish to measure left ventricle peak filling rate and passive
atrial emptying fraction as a measure of cardiac diastolic function. The investigators
hypothesize that classic T2DM markers such as levels of urinary albumin excretion,
retinopathy, autonomic neuropathy, hypertension, dyslipidemia, elevated HgbA1c, T2DM
duration, etc. are associated with pathological findings by CMR.
2. Patients with T2DM have impaired left ventricle myocardial perfusion as determined by
gadolinium contrast CMR. The investigators hypothesize that the classic markers and risk
factors mentioned above, are associated with left ventricle myocardial hypoperfusion as
determined by gadolinium contrast CMR.
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