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Clinical Trial Summary

This is a first-in-human, multi-center, open-label clinical study with separate dose escalation (Phase 1) and expansion (Phase 2) stages to assess preliminary safety, tolerability, and efficacy of the second generation oral XPO1 inhibitor KPT-8602 in participants with relapsed/refractory multiple myeloma (MM), metastatic colorectal cancer (mCRC), metastatic castration resistant prostate cancer (mCRPC), higher risk myelodysplastic syndrome (HRMDS), acute myeloid leukemia (AML) and newly diagnosed intermediate/high-risk MDS. Dose escalation and dose expansion may be included for all parts of the study as determined by ongoing study results.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT02649790
Study type Interventional
Source Karyopharm Therapeutics Inc
Contact
Status Active, not recruiting
Phase Phase 1/Phase 2
Start date January 2016
Completion date December 31, 2024

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