Diabetes Mellitus Clinical Trial
The study aims to evaluate the effect of smoking on postprandial responses such as plasma glucose, secretion of gut - and pancreatic hormones and gastric emptying in healthy, heavy smoking men.
Epidemiological studies show that active smoking increases the risk of type 2 diabetes in a
dose-dependent fashion. Smokers seem to be characterized by central obesity, increased
inflammatory markers and oxidative stress, which may lead to insulin resistance and
irregularities in glucose metabolism. The current study is a meal test study, in which the
aim is to examine a number of variables during a liquid mixed meal test (including gastric
emptying, glucose tolerance, gut and pancreatic hormone responses, gall bladder emptying,
appetite and food intake) performed in healthy non-smoking subjects and in healthy smokers
with or without concomitant cigarette smoking.
The investigators hypothesize that smoking-induced increases in circulating nicotine levels
and simultaneous activation of nicotinic receptors in the gastrointestinal tract and in the
autonomic nervous system would have detrimental effect on postprandial glucose metabolism
and, thus, constitute an important link between smoking and the risk of type 2 diabetes. The
current study will help to clarify this hypothesis and improve our general understanding of
the association between smoking and gut hormone secretion, gastric emptying and glucose
metabolism.
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