Pulmonary Disease, Chronic Obstructive Clinical Trial
Official title:
The Effect of Resveratrol on Metabolism and Cardiovascular Risk Profile in Patients With Chronic Obstructive Pulmonary Disease (COPD)
The primary objective is to investigate the efficacy of resveratrol on mitochondrial function in patients with COPD. The secondary objective is to investigate the effect of resveratrol on body composition, inflammatory status and mechanistic markers in blood, adipose and muscle tissue as well as a comprehensive assessment of metabolicand physical performance profile known to be affected by resveratrol.
Rationale: Patients with COPD are often chaacterized by disturbed metabolic health affecting
physical and cognitive function, which is reflected in altered body composition. current
studies in healthy subjects suggest that resveratrol improves metabolic health by enhancing
muscle mitochondrial function and adipose tissue morphology.
Study design: Proof-of-concept randomized placebo-controlled double blinded clinical trial of
4 weeks.
Nature and extent of the burden and risks associated with participation, benefit and group
relatedness: Subjects may be confronted with certain inconveniences and risks. Subjects will
be asked to wear an accelerometer two times for one week. During the entire study period
subjects will visit the MUMC+ 2 times for various non-invasive measurements (questionnaires,
anthropometry, and physical function test) as well as some minor invasive procedures (venous
blood sampling and muscle and fat biopsies) which can cause a local haematoma afterwards.
However, the patients will be informed about their metabolic and cardiovascular health, which
we expect to be positively affected by the intervention. In addition, all patients will
receive a lifestyle advice tailored to their health status.
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