Chronic Obstructive Pulmonary Disease Clinical Trial
Official title:
Inhaled Corticosteroids do Not Modify the Systemic Inflammation Induced by Exercise in Patients With Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is characterized by pulmonary and systemic inflammation. The effect of inhaled corticosteroids (IC) on inflammation in COPD is controversial.
Physical exercise produces a systemic inflammatory response, both in the healthy individual
and in the COPD patient (Rabinovitch et al ERJ 2003; van Helvoort et al Respir Med 2005;
Davidson WJ et al. J Appl Physiol). Nevertheless, although it has been described that some
of the systemic biomarkers related with COPD (Protein C-Reactive (PCR), interleukin [IL]-8)
are associated with a lower tolerance to exercise in COPD patients (García-Río et al. Respir
Res 2010), the role of IC on systemic inflammation triggered by exercise in COPD patients
remains unknown.
This study explores the hypothesis that the inflammatory response induced by exercise in
COPD patients could be with IC treatment.
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Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
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