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Clinical Trial Summary

Severe traumatic brain injury with increased intracranial pressure can lead to decreased cerebral blood flow. Low cerebral blood flow is responsible for secondary lesions, leading to bad prognosis. It is not yet established whether increasing cardiac output in these patients can lead to an increase in cerebral blood flow, although there are some arguments in favor of this hypothesis. The aim of this study is to demonstrate that increasing cardiac output will improve cerebral blood flow in patients with severe traumatic injury and high cerebral pressure.


Clinical Trial Description

n/a


Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment


Related Conditions & MeSH terms

  • Brain Injuries
  • Severe Traumatic Brain Injury With High Cerebral Pressure

NCT number NCT02019810
Study type Interventional
Source University Hospital, Grenoble
Contact Gilles Francony, MD
Phone 0033476766688
Status Recruiting
Phase Phase 2
Start date October 2014
Completion date October 2016