Other Clinical Trial - Meropenem Dosage Strategy Based on PPK Model

Status Completed

Clinical Trial Summary

To evaluate the clinical and economical benefits of a meropenem dosage strategy based on a population pharmacokinetic(PPK)-pharmacodynamic(PD) model in lower respiratory tract infection patients.

Clinical Trial Description

- Subjects:lower respiratory tract infection patients

- Study design:randomized control study.The patients in study group will accept meropenem therapy with the regimen decided by a software developed from a PPK-PD model. The patients in control group will accept meropenem therapy with the regimen decided by attending physician.

- Primary endpoint: clinical successful rate of meropenem therapy. The clinical efficiency of meropenem therapy will be evaluated one week later from stop of meropenem therapy.

- Second endpoint: amount of used antibiotics and bacteriological successful rate. ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Infection
Lower Respiratory Tract Infection
Respiratory Tract Infections

Clinical Trial Details

NCT number	NCT01944319
Study type	Interventional
Source	Peking University Third Hospital
Contact
Status	Completed
Phase	Phase 4
Start date	July 2013
Completion date	October 2015

View Details

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