Attention Deficit Hyperactivity Disorder Clinical Trial
Official title:
Near Infra-Red Spectroscopy (NIRS) in Neurodevelopmental Disorders and Typically Developing Children
Background:
- Near-infrared spectroscopy (NIRS) is a functional imaging technique that can be uses light
to study brain function while allowing for movement. To look at blood flow in the brain, NIRS
uses a low-power light source with detectors that see how the light changes as it passes
through brain tissue. Brain blood flow can indicate which parts of the brain are active
during different tasks. Researchers want to study children with attention deficit
hyperactivity disorder (ADHD) and autism spectrum disorders (ASD) and will use NIRS to
compare the blood flow in the brain of children with ADHD and ASD with that of typically
developing children.
Objectives:
- To see how well NIRS can detect changes in brain blood flow during tests of thinking and
memory in children.
- To compare blood flow in the brains of typically developing children and those with ADHD
or ASD.
Eligibility:
- Children between 4 and 8 years of age with ASD, ADHD, or children with no psychiatric
diagnoses.
Design:
- Participants will be screened for eligibility. Those who are taking stimulant medication
for ADHD or ASD will need to stop taking it for 3 days before the study visit.
- After participating in a screening assessment, all participants will have one study
visit. At this visit, they will have be asked to complete two tasks during a NIRS scan.
For both tasks, they will react to images on a computer screen. This visit will last
about 2 hours.
- This is a testing study only. No blood or other samples will be needed for this study.
Objective: to test whether Near Infra-Red Spectroscopy (NIRS) can be used to monitor
cognitive brain function and detect markers for differentiation of Autism Spectrum Disorders
(ASD) and Attention Deficit Hyperactivity Disorder (ADHD).
Study population: Children with ASD, ADHD, and typically developing children, all between 4
and 8 years of age.
Design: The study will investigate NIRS signal changes while children with ASD, ADHD, and
typically developing children perform well-known functional tasks.
Outcome Measures: Graded changes in blood flow and oxygen, measured with NIRS, in response to
different functional tasks.
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