Chronic Obstructive Pulmonary Disease (COPD) Clinical Trial
Official title:
Effects of Neuromuscular Electrical Stimulation as an Adjunct to Exercise Training in Stable COPD
Skeletal muscle dysfunction impairs exercise capacity, quality of life and prognosis in chronic obstructive pulmonary disease (COPD). The purpose of this prospective randomized controlled study was to evaluate effects of Neuromuscular electrical stimulation (NMES) plus quadriceps muscle training (NMES group) and sham NMES plus quadriceps muscle training (control group) on muscle function, exercise capacity, health related quality of life, activities of daily living, and self-efficacy in patients with COPD who are eligible and able to participate in endurance training.
Skeletal muscle dysfunction is common and impaires exercise capacity in patients with
chronic obstructive pulmonary disease (COPD)Exercise training is the main component of the
treatment of COPD.
Neuromuscular electrical stimulation (NMES) is successful in COPD patients who are unable to
perform exercise training. The NMES has positive effect on peripheral muscle function,
exercise capacity and breathlessness in activities of daily living in COPD patients who had
an abnormal body composition or who were too dyspneic to leave their home. A nonrandomized
uncontrolled study has shown that application of NMES at home for improved exercise capacity
in patients with better-preserved muscle mass. Evidence from a preliminary study without
applying sham NMES revealed that NMES applied as complementary to ambulatory respiratory
rehabilitation program increased quadriceps strength, quality of life and six minute walk
distance in severe to very severe patients.
Despite documented benefits of NMES in COPD patients, the place of NMES as an adjunct to
pulmonary rehabilitation in COPD patients who were able to do regular endurance and strength
training on is unknown. Therefore, the purpose of this study was to compare the effects of
NMES plus quadriceps muscle training (NMES group) and sham NMES plus quadriceps muscle
training (control group) on muscle function, dyspnea, fatigue, exercise capacity, health
related quality of life, activities of daily living, and self-efficacy in patients with COPD
who are eligible and able to participate in endurance training.
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Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment
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