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Aprepitant for Postoperative Nausea and Vomiting in Laparoscopic Hysterectomy

Postoperative Nausea and Vomiting Clinical Trial

Clinical Trial Summary

- Gynecological surgery is associated with a high incidence of postoperative nausea and vomiting.

- NK1 receptor antagonists such as aprepitant appear to be highly effective for treating acute and delayed emesis, and yet understanding of the efficacy of different doses of aprepitant is limited.

- We performed a prospective, randomized, double-blinded placebo-controlled study of 123 female adults scheduled for laparoscopic hysterectomy who received 80 mg aprepitant, 125 mg aprepitant, or a placebo.

Clinical Trial Description

123 female patients (ages 21-60) undergoing laparoscopic hysterectomy

1. 80mg aprepitant

2. 125mg aprepitant

3. placebo

Incidences of nausea, vomiting/retching, and use of rescue antiemetics were recorded at 0, 1, 2, 24, and 48 h after surgery. ;

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01440673
Study type Interventional
Source Gachon University Gil Medical Center
Contact
Status Completed
Phase N/A
Start date March 2010
Completion date September 2010
View Details
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