Diabetes Mellitus Type 2 in Obese Clinical Trial
Official title:
TODAY2 Phase 1 Immediate Post-Intervention Observational Follow-up Study of the TODAY Clinical Trial Cohort
The purpose of this study is to continue to follow participants in the TODAY clinical trial as they transition to non-blinded, non-randomized standard diabetes care and management with monitoring and follow-up for up to 24 months (phase 1), during which time the TODAY data are analyzed and findings interpreted to develop a long-term observational protocol (phase 2). Data are collected during phase 1 for descriptive purposes; there is no primary hypothesis.
TODAY (Treatment Options for type 2 Diabetes in Adolescents and Youth) was a multi-center study of the optimal approach to treatment of type 2 diabetes (T2D) in children and adolescents. The TODAY clinical trial of experimental interventions ended in February 2011. It is followed by TODAY2, a longitudinal study to continue the care and observation of the TODAY cohort beyond the end of the TODAY intervention trial. TODAY2 consists of two phases. 1. First is the immediate transition of TODAY participants to non-blinded, non-randomized standard diabetes care and management with monitoring and follow-up for up to 24 months. During this period, the findings of TODAY are analyzed and interpreted by the study group. 2. The second phase is a protocol for long-term longitudinal follow-up of the TODAY cohort, based on findings from TODAY. The primary objective of the first phase of TODAY2 is to continue to follow the TODAY subjects for up to 24 months in order to begin to: - understand the persistence of the effects of the different treatment regimens used in TODAY, - describe the continued evolution of beta cell function, and - describe the development of vascular complications and risk factors for complications. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Withdrawn |
NCT02668328 -
Cochlear-Vestibular Ganglion (CVG) in Newly Diagnosed Type 2 Diabetes Patients
|
N/A | |
| Completed |
NCT04314427 -
Early Glycaemic Control in Type 2 Diabetes Patients After Bariatric Surgery; ECODABS
|
||
| Recruiting |
NCT05942079 -
"The Effect of Reiki on Metabolic Parameters in Obese Type 2 Diabetes Patients''
|
||
| Not yet recruiting |
NCT06333132 -
Deciphering the Role of Incretin Hormones in Weight Loss-induced Remission of Type 2 Diabetes (DIABeat)
|
N/A | |
| Active, not recruiting |
NCT05579561 -
Vegetarian Ketogenic Diet VS Omnivore Ketogenic Diet - Protocol of a Keto-vege Diet for Remission of Type 2 Diabetes
|
N/A | |
| Completed |
NCT02938026 -
Changes of Diet, Physical Activity and Sleep Pattern and Their Effects on Glycemic and Weight Control in Hong Kong Chinese Obese Patients With Type 2 Diabetes After Bariatric Surgery Compared to Telephone Intensive Lifestyle Counselling
|
N/A | |
| Recruiting |
NCT05887271 -
A Randomised, Controlled Trial of a Low-energy Diet for Improving Functional Status in Heart Failure With PRESERVED Ejection Fraction Preserved Ejection Fraction
|
Phase 2/Phase 3 | |
| Completed |
NCT02680873 -
Efficacy of SASI Bypass for Type-2 Diabetic Obese Patients
|
N/A | |
| Not yet recruiting |
NCT05711043 -
The GATE Trial: Endoscopic Sutured Gastroplasty in Type 2 Diabetic, Obese Patients Using the Endomina Device
|
N/A | |
| Completed |
NCT02784275 -
A Study to Evaluate the Efficacy and Safety of Cyclo-Z in Patients With Obese Type 2 Diabetes
|
Phase 2 | |
| Recruiting |
NCT01874366 -
Determination of Safety,Tolerability,Pharmacokinetics,Food Effect& Pharmacodynamics of Single & Multiple Doses of P11187
|
Phase 1 | |
| Recruiting |
NCT03821636 -
Impact of Long Alimentary Limb or Long Biliary Limb Roux-en-Y Gastric Bypass on Type 2 Diabetes Remission in Severely Obese Patients.
|
N/A | |
| Recruiting |
NCT03904901 -
Influence of Probiotics in Diabetic Cardiopathies With Excessive Weight
|
N/A | |
| Active, not recruiting |
NCT01989988 -
DMBSS-A Randomized Trial of Different Laparoscopic Gastric Bypass Surgery in Patients With Obesity-related T2DM
|
N/A | |
| Completed |
NCT02122874 -
Percutaneous Electric Neurostimulation of Dermatome T7 Improves Glycemic Profile in Obese and Typo 2 Diabetic Patients
|
Phase 3 | |
| Completed |
NCT03394157 -
Randomized Comparative Study of Sleeve Gastrectomy Versus MGB and SASI Bypass , Randomized Study
|
N/A | |
| Recruiting |
NCT04227769 -
IL-1-receptor Antagonist During Cephalic Phase of Insulin Secretion in Health and Type 2 Diabetes
|
Phase 2 | |
| Active, not recruiting |
NCT05755321 -
From Skin Fibroblasts to Neural Stem Cells to Investigate in Vitro the Impact of Diabetes on Adult Neurogenesis
|
||
| Completed |
NCT04957589 -
VLCD & Adjuvant Exercise Effect in Overweight Diabetic Men
|
N/A | |
| Recruiting |
NCT05801614 -
Normalized Glucose Levels in Type 2 Diabetes With Carbohydrate or Caloric Restriction
|
N/A |