Diabetes Mellitus Clinical Trial
Official title:
Does Domperidone, a D2-antagonist Alter Gastric Emptying Rates and Appetite Sensations in Healthy Adults?
The purpose of this study is to determine whether domperidone was sufficient to accelerate gastric emptying of a high-fat solid meal and reduce satiety responses in a healthy adult population.
This study aims to investigate the effect of domperidone on gastric emptying and appetite
sensations in healthy subjects. Domperidone is a dopamine 2 (D2) receptor antagonist with
claims of gastrointestinal tract pro-kinetic activity. Accelerated gastric emptying (GE) may
lead to reduced satiation, increased food intake and is associated with obesity and diabetes
mellitus. It is hypothesized that domperidone will increase gastric emptying rate and reduce
satiety responses to a high-fat meal.
The effect of acute oral administration of 10 mg domperidone on gastric emptying of a
high-fat pancake test meal, and subjective appetite sensations by visual analogue scale will
be measured for six hours postprandially in a randomized, placebo-controlled, single-blinded
manner in 13 healthy subjects.
;
Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Single Blind (Subject), Primary Purpose: Basic Science
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