Dexpanthenol Mouthwash to Treat Oral Mucositis

Oral Mucositis (Ulcerative) Due to Radiation Clinical Trial

Official title: Effects of Topical Dexpanthenol on Chemotherapy and Radiotherapy Induced Oral Mucositis

Status Recruiting

Clinical Trial Summary

Oral mucositis can be a significant problem for cancer patients. It is typically associated with pain and increased risk of infection and can lead to impaired nutritional status and inadequate hydration.it can be seen in the patient population receiving high-dose head and neck radiation therapy (85%-100%). Topical dexpanthenol acts like a moisturizer, improving stratum corneum hydration, reducing transepidermal water loss and maintaining skin softness and elasticity. The stimulation of epithelization, granulation and mitigation of itching were the most prominent effects of formulations containing dexpanthenol. The investigators suppose that dexpanthenol mouth wash may improve oral mucositis.

Clinical Trial Description

Patients will be given a bottle of 5% Dexpanthenol mouthwash and they are asked to rinse 10 ml of it three times a day. At the onset of mucositis and then for 4 subsequent weeks they will be examined to evaluate the condition of their oral mucosa.By the advent of mucositis stage 4 ,at any time during the 4 weeks of study,the patient would be out.if any patient shows allergic reaction to dexpanthenol,he/she would be out of study too. ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Related Conditions & MeSH terms

• Mucositis
• Oral Mucositis (Ulcerative) Due to Radiation
• Stomatitis

• NCT number: NCT01318889
• Study type: Interventional
• Source: hahid Beheshti University of Medical Sciences
• Contact: Fahimeh Anbari, resident
• Phone: +98 9197263620
• Email: fahimeh.anbari@gmail.com
• Status: Recruiting
• Phase: Phase 2
• Start date: September 2010
• Completion date: September 2011