Infection, Human Immunodeficiency Virus I Clinical Trial
Official title:
A Phase 1, Open Label, Single Sequence, Two-Way Drug Interaction Study Evaluating Plasma GSK2248761 and GSK1379572 Pharmacokinetics in Healthy Adult Subjects
This is a single-center, open-label, three-period, fixed-sequence cross over study in healthy adult subjects. A total of approximately 16 healthy subjects will be enrolled to provide data from 12 evaluable subjects. Subjects will have a screening visit within 30 days prior to the first dose of study drug, three treatment periods, and a follow-up visit 7-14 days after the last dose of study drug. There will be a washout period between Period 1 and Period 2 but no washout between Period 2 and Period 3. Day 1 of Period 3 will be the day after Day 5 of Period 2.
ViiV Healthcare is the new sponsor of this study, and GlaxoSmithKline is in the process of updating systems to reflect the change in sponsorship ;
Allocation: Randomized, Endpoint Classification: Pharmacokinetics Study, Intervention Model: Crossover Assignment, Masking: Open Label
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03327740 -
PRJ2203: Dolutegravir Post Authorization Safety Study (PASS)
|
||
| Completed |
NCT00257621 -
GW640385 Plus Ritonavir And NRTIs For 48 Weeks In HIV-1 Infected Adults
|
Phase 2 | |
| Completed |
NCT01227824 -
A Trial Comparing GSK1349572 50mg Once Daily to Raltegravir 400mg Twice Daily
|
Phase 3 | |
| Completed |
NCT01597648 -
A Study to Evaluate the Bioequivalence of a Combined Formulated Tablet Compared With Maraviroc and Combivir™
|
Phase 1 | |
| Completed |
NCT01205243 -
ZIAGEN® Post-marketing Surveillance
|
||
| Completed |
NCT00450580 -
HIV-1 Infection Study of Once a Day Versus Twice a Day Protease Inhibitor in Antiretroviral Treatment Naive Adults
|
Phase 3 | |
| Completed |
NCT00440947 -
Induction/Simplification With Atazanavir + Ritonavir + Abacavir/Lamivudine Fixed-Dose Combination In HIV-1 Infection
|
Phase 3 | |
| Completed |
NCT00549198 -
KIVEXA Vs TRUVADA, Both Administered With Efavirenz, In ART-Naive Subjects
|
Phase 4 | |
| Completed |
NCT00481390 -
Prospective Epidemiological Study Of The Prevalence Of HLA-B*5701 In HIV-1 Infected Patients
|
N/A | |
| Completed |
NCT00242840 -
Observational Study Of A Protease Inhibitor (PI) Containing Regimen In Subjects With PI Mutations Selected During Prior Treatment With GW433908 (Fosamprenavir)
|
Phase 3 | |
| Terminated |
NCT00197145 -
Study Of Chemokine Coreceptor 5 (CCR5) Antagonist GW873140 In R5-Tropic Treatment-Experienced HIV-Infected Subjects
|
Phase 3 | |
| Completed |
NCT00089583 -
48-Week Study Of GW433908 And Ritonavir Or GW433908 Alone, Twice Daily In Pediatric Patients With HIV Infection
|
Phase 2 | |
| Completed |
NCT00044577 -
New Tablet Containing Two FDA Approved Anti-HIV Drugs For Antiretroviral Therapy Experienced HIV-1 Infected Subjects
|
Phase 3 | |
| Terminated |
NCT00104429 -
GW873140 In Combination With Combivir In HIV Infected Subjects
|
Phase 2 | |
| Completed |
NCT01263015 -
A Trial Comparing GSK1349572 50mg Plus Abacavir/Lamivudine Once Daily to Atripla (Also Called The SINGLE Trial)
|
Phase 3 | |
| Terminated |
NCT00102778 -
GW873140 In Combination With Kaletra In HIV Infected Subjects
|
Phase 2 | |
| Completed |
NCT00094523 -
Fosamprenavir Versus Other Protease Inhibitors
|
Phase 3 | |
| Completed |
NCT00046176 -
A HIV Study Of A Fixed-Dose Combination Tablet In Antiretroviral Experienced Patients
|
Phase 3 | |
| Terminated |
NCT00242879 -
A Dose Ranging Study Of GW640385 Boosted With Ritonavir (Rtv) In Comparison To A RTV-Boosted Protease Inhibitor (PI) In HIV-1 Infected PI-Experienced Adults
|
Phase 2 | |
| Completed |
NCT00082394 -
A Study Comparing The Safety, Tolerability and Efficacy of Trizivir VS Combivir & Atazanavir In Subjects With HIV
|
Phase 4 |