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REVEAL: Randomized EValuation of the Effects of Anacetrapib Through Lipid-modification — REVEAL  

Atherosclerotic Cardiovascular Disease Clinical Trial

Official title:
REVEAL: Randomized EValuation of the Effects of Anacetrapib Through Lipid-modification. A Large-scale, Randomized Placebo-controlled Trial of the Clinical Effects of Anacetrapib Among People With Established Vascular Disease

Clinical Trial Summary

The Randomized EValuation of the Effects of Anacetrapib Through Lipid-modification (REVEAL) trial aims to determine whether lipid modification with anacetrapib 100mg daily reduces the risk of coronary death, myocardial infarction (MI) or coronary revascularization (collectively known as major coronary events) in patients with circulatory problems who have their Low-density Lipoprotein (LDL) cholesterol level treated with a statin.

Clinical Trial Description

Sub-study: Does anacetrapib as a CETP inhibitor lead to mobilization of stem cells and enhance myocardial function via neoangiogenesis and tissue regeneration? Following the main on-treatment part of the study, there was a further period of at least 2 years during which participants were followed-up by telephone, off treatment. All participants stopped study treatment prior to February 2017 (results for the main-trial have been reported) and direct participant follow-up was completed in April 2019. In the UK we will continue to collect information on health outcomes via central data registries and NHS sources for many years. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01252953
Study type Interventional
Source University of Oxford
Contact
Status Active, not recruiting
Phase Phase 3
Start date June 2011
Completion date January 31, 2037
View Details
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