Chronic Obstructive Pulmonary Disease Clinical Trial
Official title:
Pathophysiological Mechanisms of Dyspnea and Activity-Limitation in Mild COPD
Chronic obstructive pulmonary disease (COPD) is a growing cause of death, disability and
health care costs in Canada. Nevertheless, COPD remains largely under-diagnosed and
under-treated, particularly in its early stages. Patients with mild COPD have variable
respiratory symptoms and often go unrecognized by their caregivers. Recent studies indicate
that even smokers with near normal breathing test results can have extensive small airway
disease/dysfunction at rest, which becomes more pronounced during the stress of exercise
thus leading to unpleasant breathing difficulty. This study seeks to better understand the
nature and causes of breathing discomfort and activity limitation in a group of patients
with mild COPD. The investigators will compare detailed tests of small airway function and
conduct an evaluation of several key physiological parameters during the stress of exercise
in patients with mild COPD and in healthy, age-matched, non-smoking control subjects. The
investigators will also compare detailed physiological responses to exercise under
conditions of chemical loading and mechanical unloading of the respiratory system in
patients with mild COPD.
The proposed study will be the first to systematically test the hypothesis that
pathophysiological abnormalities in ventilatory demand, pulmonary gas exchange, small airway
function, dynamic ventilatory mechanics and respiratory muscle function contribute
significantly to exertional dyspnea and activity-limitation in patients with mild COPD. This
study will be the first to determine if these abnormalities can be manipulated.
n/a
Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor)
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