Chronic Obstructive Pulmonary Disease Clinical Trial
Official title:
Systemic Endothelial Abnormalities in COPD Measured by Radial Artery Applanation Tonometry (RAAP)
The purpose of this project is to validate the peripheral arterial pressure waveform measurements technique of RAAP (radial artery applanation tonometry), in patients with moderate and severe COPD (Chronic Obstructive Pulmonary Disease), and to assess the degree of systemic endothelial dysfunction in these patients compared to cigarette smokers with normal lung function and non-smokers with normal lung function.
Patients with moderate and severe COPD (GOLD stage II and III) will be studied and their
results will be compared with age-matched healthy non- smokers and smokers.
RAAP will be taken every 5 minutes for 15 minutes before salbutamol and every 5 minutes for
another 15 minutes after salbutamol.
Several parameters of lipoprotein profiles, anti-oxidant plasma capacity, inflammatory
cytokines, hormones, growth factors and vascular cell adhesion molecules will be studied in
blood. In addition, several inflammatory and oxidative markers will be studied in exhaled
breath condensate. Lung function and impulse oscillometry will be made to investigate airway
resistance, and exhaled NO (nitric oxide) at different expiratory flows will be measured to
assess alveolar and bronchial NO. Clinical assessment including dyspnoea and depression
scores will also be made.
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