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Filter by:This is a Phase 1, single center, randomized, two-period crossover study in healthy male and female subjects designed to evaluate the relative bioavailability (BA) and safety at steady state of two formulations of nimodipine: GTX 104 (nimodipine for intravenous [IV] infusion; test formulation) and nimodipine oral capsules, RS (reference formulation).
Maturity onset diabetes of the young (MODY) is a subtype of diabetes which is caused by mutations in specific genes leading to diabetes. The most common cause of MODY is due to mutations in the gene hepatocyte nuclear factor 1 alpha (HNF1A) and is consequently named HNF1A-MODY (or MODY3). HNF1A-MODY is associated with urinary excretion of glucose at lower blood glucose levels compared to other types of diabetes. Normally, glucose is reabsorbed by sodium-glucose cotransporter 2 (SGLT2), but SGLT2 is downregulated due to the mutation in HNF1A. Investigators aim to evaluate the impact of the decreased expression of SGLT2 on glucosuria in patients with HNF1A-MODY compared to patients with type 2 diabetes (T2D) using a single dose of an SGLT2 inhibitor during a glucose clamp experiment.
Unhealthy lifestyle represents a key element fueling the non-alcoholic fatty liver disease (NAFLD) onset and worsening. The investigators aimed to evaluate the effects of confinement-related lifestyle changes experienced during the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) pandemic on NAFLD evolution. A retrospective cohort of NAFLD patients was followed two years before and two years during the pandemic. At three identified time points [baseline (January 2018: T0), intermediate (January 2020: T1), and end of study (January 2022: T2)], anthropometrical, biochemical, nutritional, bioelectrical impedance analysis (BIA) data and non-invasive tools measurements were collected.
This is a Phase 2a Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Study to Evaluate the Safety, Efficacy, Pharmacokinetics, and Pharmacodynamics of Orally Administered TERN-501 as Monotherapy as well as in Combination with TERN-101 in Noncirrhotic Adults with Presumed Non-Alcoholic Steatohepatitis (NASH)
Proliferative diabetic retinopathy (PDR) is the most common causes of irreversible blindness in diabetic retinopathy (DR).Although pars plana vitrectomy (PPV) is the cornerstone for treatment of advanced PDR, related postoperative complications such as recurrent VH, NVG, and postoperative fibrovascular proliferation progression may still cause serious visual impairment. Preoperative intravitreal injections of anti-VEGF drugs may represent a new strategy for making vitrectomy safer and more effective for severe PDR.
Percussion massage therapy has gained popularity in the therapeutic and athletic communities over the past few years. Percussion massage therapy devices are extremely convenient to use, both for self-administration and by a physiotherapist. Percussion massage therapy in deep and superficial tissues; is used in many areas such as reducing pain, increasing blood circulation, improving scar tissue, reducing lactate level and muscle spasms, increasing lymphatic flow, inhibiting Golgi reflex, increasing range of motion, and is frequently used today. Vibratory massage techniques have been shown in many studies to improve joint range of motion and muscular strength. It has been argued that there aren't enough studies on this topic in the literature. Specially tailored treatments are utilized in the clinic to reduce injury frequency, improve muscular performance, and increase the flexibility of musculotendinous components. Various stretching methods are used to increase muscle length. Athletes use stretching exercises to improve joint range of motion and long-term performance. Furthermore, it is incorporated in the warm-up period of athletes' training plans to prepare for an activity or to cool down after an applied exercise. Many studies using the dynamic stretching approach have found that dynamic stretching exercises performed before an activity or a sport have a positive effect on performance and flexibility parameters. Instrument-assisted soft tissue mobilization (IASTM) is a treatment method used to reduce pain, improve joint range of motion, and mobilize soft tissue using specially designed stainless steel instruments based on the principles developed by James Cyriax. The removal of scar tissue is one of the most important goals of IASTM. Microvascular bleeding occurs with localized inflammation as a result of IASTM application, nutrient and oxygen flow is delivered, fibroblast migration increases and the healing process begins again. At the same time, secondary collagen synthesis begins and is rearranged, which allows the regeneration of the injured tissue. As a result, it treats scar tissue, adhesions, and adhesions in the fascia. IASTM is a very effective approach in fascia tissue and is widely used to offer a mobilizing stimulus in the treatment of myofascial problems.
The purpose of the study is to determine if an oral ketone beverage is safe and well-tolerated during moderate intensity exercise in participants with long-chain fatty acid oxidation disorders and if it will raise blood ketones to levels similar to that reported among normal healthy subjects.
Investigators will conduct a pragmatic randomized trial to investigate the non-inferiority of restricted use of invasive arterial lines compared to standard arterial line use.
implant stability is the first requirement for implant success. the aim is to assess whether different implant site preparation technique may impact the value of the primary stability.
Radial approach is widely established in cardiac diagnostic and therapeutic treatments. It has been shown to decrease bleeding, vascular problems, and mortality rates when compared to the femoral approach. It also offers better comfort to patients through early mobility and lowers hospital expenses. Previously, there were no specific devices for radial artery hemostasis. Many different types of dressings were used in various hospitals with no standardization. This raises the question of whether specific devices surpass dressings in terms of patient comfort, time required to maintain hemostasis, and vascular complications. The primary goal of this study was to examine the effectiveness of compression dressings and hemostatic wristbands on patients undergoing cardiac procedures via radial approach in terms of patient comfort, time required to maintain hemostasis, and vascular problems. The hemostatic wristband TR BandR (Terumo Corporation, Tokyo, Japan) was utilized in one group, while compressive elastic dressing, standardized as 13 threads gauze overlapped, opened, longitudinally pleated once and wrapped, making a 5-cm long cylinder, 1-cm in height, was used in the other.