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Filter by:Vans are the fastest-growing category of licensed road vehicle in the UK with growing carbon dioxide (CO2) emissions. The proposed research into how Unmanned Aerial Vehicles (UAVs) and land logistics systems can be combined and managed will provide fundamental new understanding into the impacts of regulation and operating criteria on energy efficiency and costs. Medical logistics could be the first domain to utilise UAVs on a commercial scale, with preliminary analysis on pathology logistics within Southampton indicating that UAVs would significantly reduce CO2 emissions. With the National Health Service (NHS) spending an estimated £2.5 billion annually on pathology logistics and with patient numbers rising, there is a need to re-think how logistics costs could be reduced whilst improving bleed-to-diagnosis times for patients and energy demand. The research vision is to examine the energy reduction potential of logistics solutions involving UAVs operating alongside sustainable last-mile delivery solutions (cargo cycles and walking porters via micro-consolidation points). This involves understanding UAV operations in airspace shared with manned aircraft. The project focuses on a case study and trials based around NHS pathology sample transportation in the Solent and Dorset region. The key research objectives are to: 1. Investigate the collective transport and energy impacts of current 'business-as-usual' NHS pathology logistics across the Solent region; 2. Develop new simulation tools to quantify the energy consumption of UAVs and land logistics systems resulting from new types of traffic regulation for shared airspace and the operating requirements of UAVs; 3. Evaluate the impact on air space and energy use of a large scale take-up of UAVs for medical logistics across the Solent region; 4. Understand stakeholder concerns about UAVs; 5. Understand the regulatory and governance needs associated with UAV interventions that will lead to energy benefits in logistics.
The PReSent study seeks to clarify the need, develop and test the feasibility and acceptability of a shared decision making intervention to support patients with Chronic Obstructive Pulmonary Disease make decisions about Pulmonary Rehabilitation. The study is split into two parts; (1) an observational study of healthcare professionals implicit attitudes, and (2) a feasibility and acceptability study assessing the value of the newly developed shared decision making intervention including a patient decision aid and decision coaching.
This study will consider the safety and effectiveness of a study drug, CAN04, in combination with FOLFIRINOX, in the treatment of metastatic pancreatic ductal adenocarcinoma.
Postoperative pancreatic fistula (POPF) is a major complication and an important cause of mortality after pancreaticoduodenectomy (PD). Trans-nasal afferent loop decompression technique (TNALD) may reduce the rate of POPF based on our previous retrospective study. The aim of this open-label randomized controlled trial is to determine whether TNALD is a protective factor against the development of POPF after PD.
This is a Phase II, open-label, single-arm, multicentre, study in China assessing the efficacy and safety of T-DXd in participants with HER2-expressing advanced gastric or GEJ adenocarcinoma who have received at least 2 prior regimens including a fluoropyrimidine agent and a platinum agent
Evaluate the safety, tolerability, and efficacy of OTX-TKI for intravitreal use in subjects with Neovascular Age-Related Macular Degeneration
The goal of this study is to compare the usability of a novel, medication-related clinical decision support (CDS) application to the current standard medication administration and documentation workflow. The study will occur in a simulation setting, using a manikin and test patient data - no actual patients will participate. Forty clinician participants will be randomly assigned to either the CDS group (who will complete simulation tasks using the CDS prototype) or the Control group (who will complete simulation tasks using the standard medication administration workflow).
The main purpose of this study is to investigate whether an online lifestyle modification program for people with Metabolic Associated Fatty Liver Disease (MAFLD) through a mobile application produces a significant reduction in liver steatosis and is associated with a higher rate of weight loss compared to standard recommendations currently indicated in Primary Care.
The aim of the randomized, double-blind, placebo-controlled, one-period effectiveness study is to compare the effects of multiple-dose 12 weeks daily dietary supplementation with 10 g collagen alone or 5 g or 10 g of collagen in combination with MSM on skin in healthy human subjects in comparison to placebo product. The main objective is to show that test products have beneficial effects on dermis density, and also on other skin parameters and to investigate differences in the effects among test products.
36 participants who have mild crowding from the Orthodontic Department at University of Damascus Dental School will be randomly assigned into two groups. 1. In the experimental group, patients will be treated using single aligner appliance in order to align their crowding teeth. 2. Control group will undergo typical orthodontic treatment using an MBT-prescription of metallic brackets.