Osteoporosis Clinical Trial
Official title:
"Levels of RANKL and OPG in Gingival Crevicular Fluid of Patients With Post-menopausal Osteoporosis / Osteopenia and Periodontal Disease."
The aim of this study was to investigate the levels of RANKL and Osteoprotegerin, and their
relationship in gingival crevicular fluid of post-menopausal women with
osteoporosis/osteopenia and chronic periodontitis simultaneously and evaluate the effect
that the use of bisphosphonates in periodontal disease.
Study hypothesis:
"The osteoporosis / osteopenia in postmenopausal women patients with periodontal disease
affect the ratio RANKL / OPG in gingival crevicular fluid samples favoring
osteoclastogenesis processes "
81 active periodontal sites from 31 postmenopausal women aged 45-70 years with chronic
periodontitis were studied. Samples of gingival crevicular fluid were collected by paper
strips and ELISA test was conducted to determine the total concentration of RANKL, OPG, and
then obtain the values of the RANKL / OPG ratio. We analyzed 66 samples of gingival
crevicular fluid obtained from active periodontal sites of 17 patients with osteopenia /
osteoporosis and 15 samples gingival crevicular fluid obtained from active periodontal sites
obtained of 14 controls patients with normal osseous condition.
Statistical analyzes were computed and analyzed using Graphpad Software. To determine if the
data correspond to a normal distribution the D'Agostino-Pearson test was used. The values of
cytokines (RANKL and OPG) and its ratio (RANKL / OPG) were compared using Mann-Whitney Test
t U. Analysis Spearman correlation and linear regression for statistic was also performed to
determine whether there was any relationship between the variables analyzed. It was
considered as statistically significant p value ≤ 0.05.
;
Observational Model: Case Control, Time Perspective: Cross-Sectional
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