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Osteoarthritis clinical trials

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NCT ID: NCT04201743 Withdrawn - Clinical trials for Osteoarthritis, Knee

An Amniotic Membrane Injection Comparing Two Doses (1 mL and 2mL Injection) in the Treatment of Osteoarthritis of the Knee

Start date: March 30, 2020
Phase: Phase 4
Study type: Interventional

The purpose of this study is to determine the dose effect of a single injectable acellular amniotic membrane derived allograft injection for the treatment of knee osteoarthritis and to confirm whether the use of 2 mL of the same amniotic injection offers a statistically significant advantage over the 1 mL injection.

NCT ID: NCT04199481 Withdrawn - Clinical trials for Osteoarthritis, Knee

Univation XM France

Start date: August 2020
Phase:
Study type: Observational

The study is set up due to regulatory purposes and to collect routine clinical data of the mobile-bearing implant univation XM. The study is designed as a prospective follow-up study with a historic patient cohort who have been treated with the product under investigation two years ago. This design is selected to quicker realize follow-up data as patients have already been treated in the past. As the mobile version of the implant is not widely used, the study will be set up as a monocentric study in France. The clinical hypothesis of the study is that patients who are treated with the product under investigation have a similar outcome and survival rate in comparison to other established unicondylar knee systems on the market. Comparison for the later evaluation will be taken out of recent orthopaedic registries.

NCT ID: NCT04189640 Withdrawn - Knee Osteoarthritis Clinical Trials

Ultrasound-Guided Adductor Canal Block for Total Knee Arthroplasty Surgery

Start date: January 10, 2020
Phase: N/A
Study type: Interventional

The ultrasound-guided selective blockade of the saphenous nerve in the adductor canal provides effective analgesia and reduces postoperative pain in patients undergoing arthroscopic medial meniscectomy. Selective blockade of the saphenous nerve in the adductor canal provides effective analgesia without quadriceps muscle weakness. It has been shown that the adductor canal block (ACB) block increases the spread of local anesthetics in a distal and proximal way. Therefore, the proximal spread of local anesthetics may cause possible quadriceps weakness. The distal spread of local anesthetics may increase analgesic effect via sciatic nerve. The different volumes for ACB is a topic of discussion. The aim of this study is to compare the different volumes of US-guided ACB performing for postoperative analgesia management after total knee arthroplasty surgery.

NCT ID: NCT04163913 Withdrawn - Osteoarthritis Clinical Trials

Radial Medical - GAPS

Start date: November 2019
Phase: N/A
Study type: Interventional

This study will prospectively compare compliance rates between a novel FDA cleared wearable compression therapy with and without digital engagement for DVT prophylaxis in both hospital and home environments after total knee or hip arthroplasty.

NCT ID: NCT04115020 Withdrawn - Osteoarthritis Clinical Trials

Low Dose Naltrexone for Chronic Pain in Osteoarthritis and Inflammatory Arthritis

Start date: January 2020
Phase: Phase 2
Study type: Interventional

Over 100 million Americans report chronic pain. One of the most common causes of chronic pain is osteoarthritis (OA). OA is attributable to "wear and tear," but reasons for pain are complex. Inflammatory arthritis (IA) includes multiple severe diseases that affect 2-3% of persons and require treatment with immune-suppressive drugs to prevent joint destruction. Pain often persists despite effective treatment. Pain in arthritis results from multiple sources: inflammation, perception of pain in the joint, and interpretation of pain by the brain. Unfortunately, management of pain in arthritis remains a challenge. Low dose naltrexone is a widely used but unproven "alternative" approach to chronic pain. It is attractive for study because it is safe and is proposed to work on all three pathways that contribute to pain. A small but high-quality clinical trial is needed to determine whether to invest in definitive studies.

NCT ID: NCT04087304 Withdrawn - Clinical trials for Osteoarthritis, Knee

Hip and Knee Scoring System to Predict Complication Rate and Candidacy for Total Hip and Knee Arthroplasty

Start date: October 18, 2018
Phase: N/A
Study type: Interventional

This study is a prospective validation study of a new hip and knee replacement-specific questionnaire that can be used to predict postoperative complications. The purpose of this study is to confirm the validity of a new hip and knee scoring system to be used as a clinical tool to predict potential complication rates in patients undergoing total hip or knee replacement surgery. This scoring system aims to stratify patients into specific risk categories based a standardized calculated score. Patients will be evaluated on health risk factors and severity of disease on radiographic imaging prior to surgery, associated to higher complication rates following surgery. The hopeful anticipated result of this study is a prospective validation of the scoring system with both statistical and clinical significance in predicting postoperative complication rates in patients with moderate to high health risk, This stratification system may prove meaningful by allowing these patients, especially those classified as High-Risk, to be incorporated into more appropriate healthcare bundle payment systems that account for their higher financial demands. Furthermore, the stratification may allow for preoperative counseling and a shift towards non-operative management, or surgeon-patient conversations regarding the need to modify a portion of their objective risks prior to surgical intervention. Predictive risk models such as the one presented in the current study will be essential tools as the number of total hip arthroplasty procedures performed each year continue to increase and both the numbers of procedures and associated complications impose a significant cost on the U.S. healthcare system.

NCT ID: NCT04063943 Withdrawn - Osteoarthritis Clinical Trials

Long Term Sidus PMCF

Start date: July 12, 2019
Phase: N/A
Study type: Interventional

The objectives of this study are to assess the safety and performance of the Sidus Stem-Free Shoulder Arthroplasty System in unilateral primary total shoulder arthroplasty.

NCT ID: NCT04057885 Withdrawn - Clinical trials for Degenerative Arthritis

To Determine the Gait and Functional Improvement in Total Knee Arthroplasty

Orthosensor
Start date: May 15, 2017
Phase: N/A
Study type: Interventional

This is an observational study to understand the effects of soft-tissue balancing on gait, function and rehabilitation potential after sensor-assisted Total Knee Arthroplasty

NCT ID: NCT04044742 Withdrawn - Clinical trials for Osteoarthritis, Knee

A Phase 3 Study to Evaluate the Efficacy and Safety of Resiniferatoxin for Pain Due to Osteoarthritis of the Knee

Start date: December 2020
Phase: Phase 3
Study type: Interventional

This study evaluates the efficacy and safety of intra-articular injection of resiniferatoxin in patients with moderate to severe knee pain due to osteoarthritis.

NCT ID: NCT03975101 Withdrawn - Knee Osteoarthritis Clinical Trials

Very Small Embryonic-like Stem Cells for Knee Osteoarthritis

Start date: July 5, 2019
Phase: Phase 1/Phase 2
Study type: Interventional

The aim of this study is the safety and efficacy of autologous very small embryonic-like stem cells(VSELs) to knee osteoarthritis.