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Degenerative Arthritis clinical trials

View clinical trials related to Degenerative Arthritis.

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NCT ID: NCT05441462 Completed - Clinical trials for Inflammatory Arthritis

Kinematics of Silastic Joint Replacements in the Hand

Start date: April 7, 2022
Phase:
Study type: Observational

To assess in vivo the kinematics of single piece silastic joint replacements in the hand with magnetic resonance imaging

NCT ID: NCT05357664 Terminated - Osteoarthritis Clinical Trials

PINNACLE® DM RSA Study

PIN DM
Start date: October 6, 2022
Phase: N/A
Study type: Interventional

The primary objective is to establish the mean superior cup migration of the PINNACLE® Dual Mobility Construct using model-based RSA over the first two years post-implantation. The primary endpoint is the mean vertical subsidence (Y translation, also known as superior cup migration) at 2 years as measured with RSA. Additionally, the data from this study will be compared to historical PINNACLE® data obtained in study DSJ_2018_02.

NCT ID: NCT05318521 Recruiting - Clinical trials for Degenerative Arthritis

RCT, Blinded, 2-Arm Efficacy Study of IP and Placebo in Patients With Chronic Pain Related to Osteoarthritis of the Knee

Start date: December 10, 2021
Phase: Phase 3
Study type: Interventional

It is a Phase III efficacy study as the title 'A randomized, double-blind, parallel-arm study comparing the efficacy of investigational product "Ibuprofen Modified-Release Tablets 800 mg" and placebo in patients with chronic pain related to osteoarthritis of the knee.' The primary objective is to determine the analgesic efficacy of orally administered IBUMR in patients with osteoarthritis (OA) of the knee. The Secondary objectives are to compare the treatment effect on patient pain, function and stiffness between IBUMR- and placebo-treated patients as measured by the Western Ontario and McMaster Osteoarthritis Index (WOMAC), to compare the treatment effect on Patient Global Assessment on Disease Activity between IBUMR- and placebo-treated patients, to compare the treatment effect on Investigator's Global Assessment on Disease Activity between IBUMR- and placebo-treated patients, to compare the use of analgesic rescue medicine between IBUMR- and placebo-treated patients, to determine the safety profile of IBUMR.

NCT ID: NCT04825730 Not yet recruiting - Knee Arthritis Clinical Trials

Follow-up Study for Participants of Jointstem Investigator Initiated Trial by Arthroscopy

Start date: December 1, 2023
Phase: N/A
Study type: Interventional

This clinical trial is conducted to assess the long-term safety of "jointstem" in patients with degenerative knee arthritis who participated in the previous BS-JS-IIT1 investigator initiated trial.

NCT ID: NCT04821102 Not yet recruiting - Knee Arthritis Clinical Trials

Investigator Initiated Trial to Evaluate Cartilage Regeneration by Arthroscopy After JOINTSTEM Administration

Start date: July 1, 2023
Phase: N/A
Study type: Interventional

The purpose of this study is to confirm cartilage regeneration through arthroscopy after a single administration of autologous Adipose Tissue derived Mesenchymal stem cells(JOINTSTEM) in patients with degenerative arthritis of K-L grade 3

NCT ID: NCT04815070 Completed - Clinical trials for Degenerative Arthritis

Gastric Volume in Diabetic Patients Undergoing Staged Bilateral Total Knee Arthroplasty

Start date: March 29, 2021
Phase:
Study type: Observational

Aspiration of gastric contents during perioperative period is a grave complication with significant morbidity and mortality. Diabetic patients have a higher incidence of autonomic dysfunction, causing gastropathy. They are known to have gastroparesis and the consequent delayed gastric emptying which predisposes them to an increased risk of aspiration than the general population. Furthermore, other common factors can influence the gastric emptying rate, as for example, old age, pain, and the use of opioid analgesics. In the previous study, evidence of increased pain was reported in patients undergoing staged bilateral total knee arthroplasty, in whom the second operated knee had greater sensitivity (tertiary hyperalgesia) due to the surgical injury to the first operated knee. In the present study, we will evaluate the effect of old age, diabetes, surgical stress, pain, and the use of analgesics on the residual gastric volume in elderly patients undergoing staged-bilateral total knee arthroplasty.

NCT ID: NCT04206150 Completed - Clinical trials for Degenerative Arthritis

The Appropriate Level of Continuous Adductor Canal Block in Patients Undergoing Total Knee Arthroplasty (TKA)

Start date: April 2, 2020
Phase: N/A
Study type: Interventional

Adductor canal catheters are being used to provide continuous postoperative analgesia after total knee arthroplasty surgery (TKA). There is much debate about where is the best position of continuous adductor canal block in patients undergoing TKA. Therefore, the investigators aim to compare the postoperative pain at three different level of continuous adductor canal block. Ninety six patients scheduled for total knee arthroplasty will be randomly divided into the three groups. In group 1, the adductor canal catheter is inserted at femoral triangle apex (the proximal end of the adductor canal). In group 2, the adductor canal catheter is inserted femur length/15*2 cm above the location where the nerve block performed in group 1. In group 3, the adductor canal catheter is inserted femur length/15cm below the location where the nerve block performed in group 1.

NCT ID: NCT04070989 Terminated - Osteoarthritis Clinical Trials

Pinnacle RSA Study

Start date: December 3, 2019
Phase: N/A
Study type: Interventional

The primary objective is to establish the mean superior cup migration of the Pinnacle Acetabular Shell using model-based RSA over the first two years post-implantation. The primary endpoint is the mean vertical subsidence (Y translation, also known as superior cup migration) at 2 years as measured with RSA. This will be summarized for each surgical approach separately, as well as combined.

NCT ID: NCT04057885 Withdrawn - Clinical trials for Degenerative Arthritis

To Determine the Gait and Functional Improvement in Total Knee Arthroplasty

Orthosensor
Start date: May 15, 2017
Phase: N/A
Study type: Interventional

This is an observational study to understand the effects of soft-tissue balancing on gait, function and rehabilitation potential after sensor-assisted Total Knee Arthroplasty

NCT ID: NCT03990805 Completed - Knee Osteoarthritis Clinical Trials

A Phase 3 Study to Evaluate the Efficacy and Safety of JointStem in Treatment of Osteoarthritis

Start date: June 11, 2019
Phase: Phase 3
Study type: Interventional

The purpose of this study is to investigate the efficacy and safety of autologous Adipose Tissue derived Mesenchymal stem cells (JOINTSTEM®) in patient with severe Knee Osteoarthritis.