Clinical Trials Logo
  1. Home
  2. Osteoarthritis of Knee
  3. NCT02417506

Study to Assess the Effect of E-OA-07 on Acute Pain Response in Subjects Suffering From Knee OA — Osteolanc  

Osteoarthritis of Knee Clinical Trial

Official title:
A Double Blind Randomized Comparator Controlled Study to Assess the Effect of E-OA-07 (Lanconone) on Acute Pain Response in Subjects Suffering From Osteoarthritis of the Knee

Clinical Trial Summary

The repetitive motions associated with active life and many sports can increase the wear and tear to the joints that leads to decrease in flexibility and joint pain finally heading its way to osteoarthritis. Activities such as jumping, running can wear away the cartilage that supports and cushions the joints of hands and knees, causing bones to rub against each other. Injuries stemming from repetitive motions can also cause and worsen the joint pain.

Joint pain is discomfort that arises from any joint . Irrespective of the underlying mechanisms, joint pain usually originates in activation of nociceptors, or free nerve endings. Complex neuronal activation occurs, which involves not only local sensitization of joint nociceptors but also modifications in central pain pathways.

Even though, the numerous pharmacological interventions are available for joint pain, there is much debate amongst clinicians about the best approach to the treatment of joint pain. NSAIDs which is frequently used for treatment in such cases, carries concerns related to gastro-intestinal system, cardiovascular system as well as central nervous system .

Hence there is a need of a safer alternative treatment option for relieving acute joint pain which is comparable to the modern medicines, without posing concerns to the subject's general well being.

Herbs are known to be used since ages in traditional literature and do not pose any potential health concern. Inspite of such positive attributes herbs are not employed in treatment of acute pains as there is lack of evidence proving the same.

In order to address the need of the hour Enovate Biolife has invented a novel poly herbal formulation E-OA-07 (Lanconone). Lanconone has been studied previously in patients with osteoarthritis has been proven efficacious . It has a good history of marketing and is sold in the United States, with no reported adverse event related to the product. However there is no concrete evidence proving the product's acute pain relieving dynamics, hence the current study has been employed to comprehend the effect of lanconone in joint acute pain.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02417506
Study type Interventional
Source Vedic Lifesciences Pvt. Ltd.
Contact
Status Completed
Phase N/A
Start date August 2014
Completion date February 2015
View Details
See also
  Status Clinical Trial Phase
Not yet recruiting NCT03274713 - Efficacy of Electro-acupuncture Versus Manual Acupuncture on Knee Osteoarthritis N/A
Completed NCT04535596 - Blood Flow Restriction Exercises and Conservative Exercises in Knee Osteoarthritis N/A
Completed NCT03918291 - Whole-body Vibration Training on Functional Performance of the Elderly With Knee Osteoarthritis N/A
Recruiting NCT06263517 - Clinical Trial to Assess Efficacy, Tolerability of Rising Doses of Clodronate in Painful Knee Osteoarthritis Patients Phase 2/Phase 3
Completed NCT01453738 - Allogeneic Mesenchymal Stem Cells in Osteoarthritis Phase 2
Active, not recruiting NCT01027819 - Comparison of Outcomes in Mobile and Fixed-bearing Total Knee Arthroplasty Phase 4
Completed NCT01186211 - Feasibility of Outpatient Total Knee Arthroplasty
Active, not recruiting NCT00261066 - Outcome Following Orthopaedic Surgery
Completed NCT03484910 - Biofeedback With Cycling Exercise in OA Knee Patients N/A
Recruiting NCT03884374 - Pain Relief for OsteoArthritis Through Combined Treatment (PROACT) N/A
Completed NCT03492320 - Progression of Health Related Quality of Life of Patients Waiting for Total Knee Arthroplasty
Completed NCT01449552 - Temporary Clamping of Drains Combined With Tranexamic Acid Reduce Blood Loss After TKA: A Prospective RCT N/A
Completed NCT06254976 - Serum Nesfatin-1 and Human Cartilage Glycoprotein-39 Levels in Knee Osteoarthritis N/A
Completed NCT03428893 - Mobile Technology to Support Physical Therapy Exercise N/A
Completed NCT05081921 - Clinical Trial to Evaluate Safety and Efficacy of MesoCellA-Ortho Tissue-Engineered Advanced Therapy Product in Patients With Osteoarthrosis and Civilisation Diseases Phase 1/Phase 2
Completed NCT02850068 - Geniculate Artery Embolization for the Treatment of Knee Pain N/A
Active, not recruiting NCT03110172 - Short-term Efficacy of Antidepressant in Patients Underwent TKA Phase 1/Phase 2
Enrolling by invitation NCT02623660 - Microcurrent Stimulation Reduces Post-Operative Swelling and Healing Time Following Knee Replacement Surgery N/A
Completed NCT02579174 - Total Knee Replacement Component Alignment Using Manual Versus Custom Instrumentation N/A
Completed NCT00790985 - Efficacy of Flavocoxid 500 mg Compared With Naproxen 500 mg in Subjects With Moderate-severe Osteoarthritis of the Knee N/A