Short-term Efficacy of Antidepressant in Patients Underwent TKA

Status Active, not recruiting

Clinical Trial Summary

By taking certain antidepressant in early postoperative period，which is supposed to improve the psychological status of patients with osteoarthritis, explore the effect of certain antidepressant on the recovery of the early stage after the operation of knee joint replacement.

Clinical Trial Description

In this study, the investigators are going to investigate the efficacy of Duloxetine on pain, physical function, mental health and quality of life in patients underwent TKAs.

The control group is going to be given celecoxib 200mg/24h to 2 weeks after operation.On the basis of the above scheme, the treatment group is going to receiving duloxetine 60mg/24h to 8 weeks after operation.HAMD-17 scale, KSS scale, SF-36 scale and WOMAC scale will be used to evaluate the two groups before and after operation for 4 and 8 weeks. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03110172
Study type	Interventional
Source	Dalian Municipal Central Hospital
Contact
Status	Active, not recruiting
Phase	Phase 1/Phase 2
Start date	January 2017
Completion date	July 2017

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