Osteoarthritis, Knee Clinical Trial
Official title:
The Association Between Weight Loss and Changes in Physical Activity in Overweight/Obese Individuals With Knee Osteoarthritis: An Observational Cohort Study
This is a substudy to a randomised trial investigating the effect of liraglutide on body
weight and pain in overweight or obese patients with knee osteoarthritis (NCT02905864). In
the parent trial, patients will be subjected to an 8-week diet intervention phase including a
low-calorie diet and dietetic counselling, after which.they will be randomised to receive
either liraglutide 3 mg or liraglutide 3 mg placebo as an add-on to dietetic guidance on
re-introducing regular foods and a focus on continued motivation to engage in a healthy
lifestyle.
This substudy aims to investigate any changes in physical activity associated with the
initial 8-week weight loss intervention.
The investigators aim to describe changes in physical activity associated with a significant
weight loss among overweight/obese individuals with knee OA. The investigators will take
advantage of the planned trial "Effect of liraglutide on body weight and pain in overweight
patients with knee osteoarthritis: A randomised, double blind, placebo‐controlled, parallel
group, single‐centre trial" (the parent trial) in which a significant weight loss is sought
achieved over 8 weeks by means of intensive dietary counseling and meal replacement in
overweight/obese individuals with knee OA.
The investigators hypothesize that weight loss is associated with a decrease in daily time
spent physically inactive.
Physical activity is measured using accelerometer based recordings using a wearable sensor
that continuously records physical activity over the entire weight loss program (8 weeks).
The sensor is miniaturised, discretely worn on the thigh, and is waterproof. Thus the
measurements interfere minimally with the participants daily life.
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