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Obstructive Sleep Apnea clinical trials

View clinical trials related to Obstructive Sleep Apnea.

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NCT ID: NCT02533050 Terminated - Clinical trials for Obstructive Sleep Apnea

Attentional Capacity and Working Memory in Coronary Artery Disease Patients: Impact of the Presence of a Sleep Apnea Syndrome and Chronic Effects of Treatment With CPAP

CAPCORSAS
Start date: August 2014
Phase: N/A
Study type: Interventional

The presence of Obstructive Sleep Apnea Syndrome (OSAS) has a high frequency in patients victims of a coronary artery disease (CAD) (myocardial infarction, revascularization). Unlike patients seen in a sleep Laboratory with an impact on daytime functioning, CAD apneic patients do not complain in their daytime functioning. The objective of this study is to explore whether the objective cognitive assessment measures may be a good marker of the efficacy of CPAP treatment given to non-sleepy apneic CAD patients. Coronary patients with an AHI between 15 and 40 / h will be treated (or not) after randomization with CPAP treatment. The expected results are: CPAP apneic coronary patients should have a positive impact on cognitive performance, particularly on attention span and working memory measured by improvement in the Paced Auditory Serial Addition Test score (PASAT score).

NCT ID: NCT02523248 Terminated - Clinical trials for Obstructive Sleep Apnea

Comparison Between UPPP and Tonsillectomy in Adult OSA

Start date: January 2016
Phase: N/A
Study type: Interventional

The aim of this randomized control study is to evaluate the effect of tonsillectomy with or without uvulopalatoplasty in treating adults with moderate to severe sleep apnea.

NCT ID: NCT02494102 Terminated - Clinical trials for Obstructive Sleep Apnea

Evaluation of Modafinil vs Placebo for Treatment of Anesthesia Delayed Emergence in Obstructive Sleep Apnea

ModOSA
Start date: February 2016
Phase: Phase 4
Study type: Interventional

The purpose of this study is to determine whether modafinil use in patients with obstructive sleep apnea will improve postoperative delayed emergence after general anesthesia.

NCT ID: NCT02324790 Terminated - Clinical trials for Obstructive Sleep Apnea

Pilot Study of Negative Pressure Sleep Therapy System to Treat Obstructive Sleep Apnea

Start date: December 2014
Phase: N/A
Study type: Interventional

This is a pilot study to investigate the efficacy and safety of the Negative Pressure Sleep Therapy System for the treatment of obstructive sleep apnea.

NCT ID: NCT02312479 Terminated - Clinical trials for Obstructive Sleep Apnea

Safety and Performance Study of the Nyxoah SAT System for Treating OSA

Start date: December 2014
Phase: N/A
Study type: Interventional

A prospective open-label, single treatment study to assess the safety and the performance of the Nyxoah SAT system for the treatment of Obstructive Sleep Apnea

NCT ID: NCT02296840 Terminated - Clinical trials for Obstructive Sleep Apnea

Post-operative Pain Control After Pediatric Adenotonsillectomy

Start date: November 2014
Phase: Phase 4
Study type: Interventional

Adenotonsillectomy is one of the most common surgical procedures performed in the pediatric population in the United States. It is generally a well-tolerated procedure with post-operative bleeding risk ranging from 3-5% in children. Post-operative pain following adenotonsillectomy has significant morbidity and may result in prolonged hospital stay or re-admission to the hospital. Post-operative analgesia is most commonly managed with narcotic-containing pain medication. In recent years however, there is evidence that some patients may manifest increased sensitivity to narcotics, resulting in life-threatening respiratory compromise. Though there is a theoretical risk that nonsteroidal anti-inflammatory drugs (NSAIDs) increase bleeding time by disrupting platelet aggregation, evidence of detrimental effects (i.e. increased risk of postoperative bleeding) remains inconclusive for these generally well-tolerated medications. The goal of this study is to determine the incidence of post-operative bleeding and to determine the efficacy of NSAIDs in the management of post-operative pain following pediatric adenotonsillectomy, versus more commonly used narcotic pain medication. The study design will be an initial retrospective study to collect pilot data on the incidence of postoperative hemorrhage and indicators of adequate/inadequate pain control in children age 4 to 17 undergoing adenotonsillectomy. This will be followed by a prospective, randomized, single-blind controlled study in which orally-administered ibuprofen (test intervention) is compared to acetaminophen-hydrocodone (control intervention) in the postoperative period following adenotonsillectomy.

NCT ID: NCT02273089 Terminated - Clinical trials for Obstructive Sleep Apnea

CPAP to Reduce Arterial Stiffness in Non Sleepy, Moderate to Severe Obstructive Sleep Apnea (STIFFSLEEP)

STIFFSLEEP
Start date: October 2012
Phase: N/A
Study type: Observational

This study intends to determine whether continuous positive airway pressure (CPAP) can reduce arterial stiffness (measured by pulse wave velocity) in nonsleepy as well as in sleepy patients with obstructive sleep apnea .

NCT ID: NCT02180815 Terminated - Clinical trials for Obstructive Sleep Apnea

REV 002 Observational Study of the ReVENT Sleep Apnea System: Minimally Invasive Treatment for Obstructive Sleep Apnea

Start date: September 2014
Phase: N/A
Study type: Observational

The purpose of this post-market observational study is to assess the effectiveness and patient perception of benefit of the ReVENT Sleep Apnea System in patients diagnosed with Obstructive Sleep Apnea due to primary tongue base closure. The ReVENT Sleep Apnea System is a minimally invasive surgical approach to treat Obstructive Sleep Apnea. The ReVENT Sleep Apnea System consists of an implanter kit and tongue implants. The implants are permanently implanted in the tongue during a minimally invasive outpatient surgical procedure to prevent tongue base closure during sleep.

NCT ID: NCT02162433 Terminated - Clinical trials for Obstructive Sleep Apnea

The Effect of Dexmedetomidine on Airway Complications After Deep or Awake Extubation

Start date: March 2015
Phase: Phase 4
Study type: Interventional

The investigators aim to investigate the effect of dexmedetomidine on the perioperative respiratory complications in this patient population undergoing both awake and deep tracheal extubation.

NCT ID: NCT02058823 Terminated - Clinical trials for Obstructive Sleep Apnea

Intermittent Hypoxia 2: Cardiovascular and Metabolism

IH2
Start date: August 7, 2013
Phase: Phase 4
Study type: Interventional

The purpose of this study is to compare cardiovascular physiological adaptation to intermittent hypoxia (IH) of nonobese healthy subjects. The exposure will be two periods of two weeks (IH versus exposure "placebo hypoxia"). The investigators will use pharmacological tools, peripheral vasodilator (amlodipine) or specific blocker of angiotensin receptor (valsartan) versus the taking of a placebo. The allocation of the tool and the exhibition will be randomized (HI / placebo, valsartan / amlodipine). The outcome measures evaluated concern the cardiovascular system, systemic inflammation and tissular and glucose metabolism. The investigators assume an increase in arterial resistance during the intermittent hypoxia compared to the control group, these being dependent on sympathetic tone. The investigators hypothesize that the metabolic alterations that will be observed after experimental simulation (IH and fragmentation of sleep for 15 consecutive nights) will be less severe in the valsartan group than in the amlodipine group in comparison with the placebo group. A serum bank and a gene bank will be performed for the requirements of subsequent studies if necessary.