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Effect of Weight Loss on Intermuscular Adipose Tissue (IMAT) Signaling

Obesity Clinical Trial

Official title:
Effect of Weight Loss on Intermuscular Adipose Tissue (IMAT) Signaling

Clinical Trial Summary

The goal of this intervention study is to learn about how weight loss impacts molecular signaling of intermuscular adipose tissue (IMAT) in individuals with obesity. The main question it aims to answer is how inflammatory molecules secreted by IMAT promote muscle insulin resistance and inflammation, and how these same molecules are diminished after weight loss. Following screening visits involving body composition measures, blood testing, strength testing, and a thigh muscle biopsy, participants will go through a 12-week dietary intervention for weight loss. After 12 weeks, this will be followed by the same testing and biopsies that were completed before the intervention. Researchers will then compare outcomes of individuals who lost weight to individuals who did not lose weight.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06129110
Study type Interventional
Source University of Colorado, Denver
Contact Bryan Bergman, PhD
Phone 3037243919
Email bryan.bergman@cuanschutz.edu
Status Recruiting
Phase N/A
Start date January 1, 2024
Completion date December 1, 2029
View Details
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